For NP, RP, SMB and SFC applications

Bonded phases: Easy handling, suitable for all solvents

5 and 10 m particles for predictable scale-up

Reversal of elution order by selecting (R) or (S) versions

Chirality has become vitally important in the production of pharmaceuticals, agrochemicals and related products, due to the dramatically different pharmacology the various optical isomers can present, ranging from no activity through undesirable effects to having potentially catastrophic and sometimes life threatening adverse effects. This has led to the development of highly efficient chiral stationary phases (CSP) for analytical and preparative scale separations.

With more than 30 years of experience in manufacturing high quality, bonded phases with outstanding reproducibility and reliability, YMC can now offer its well tested YMC*Gel Chiral NEA in preparative particle sizes and large bulk quantities up to 200 kg/lot for preparative applications. YMC*Gel Chiral NEA is compatible with aqueous and organic solvents, and suitable for both reversed phase and normal phase separations as well as for SMB and SFC purification of polar pharmaceutical compounds. Thanks to its easy handling, excellent performance and exceptional cost-efficiency, YMC*Gel Chiral NEA is particularly convenient for the development and scale-up of chiral purification processes.

The CSP consists of a methacrylate-(a-naphthyl) amine copolymer bonded to ultra-pure wide pore YMC silica (see Fig. 1). As a result of the covalent phase bonding YMC*Gel Chiral NEA is compatible with all commonly used mobile phases and shows excellent column durability.

(R) and (S) versions of the CSP are available to provide the facility to invert the elution order of pairs of enantiomers, allowing for easy fractionation by elution of small peaks before the major peak which may otherwise be hidden under the tail of the major peak.

Scale-up

YMC*Gel Chiral NEA is easily scalable from analytical to large scale separations: The CSP is available in 5 and 10 m particle size in prepacked columns, and the 10 m material is also available in bulk for use in dynamic axial compression columns, in lot sizes up to 200 kg. Larger particle sizes for SMB applications are available on request. In addition, scout columns are available for convenient method development.

For maximum reliability, YMC*Gel Chiral NEA is subject to YMCs rigorous manufacturing and quality control. Together with YMCs well known high quality, reproducibility and technical support, it provides a significant tool for chiral purifications from bench- to production- scale.

For more information or to apply for a test column, please contact YMC Europe directly in Germany.

From headquarters located in Kyoto, Japan, YMC has gradually and consistently matured to a level of international recognition, specifically within the pharmaceutical and biotech world, as one of the leading suppliers of analytical and process-scale silica-based stationary phases for High Performance Liquid Chromatography, preparative equipment, custom purification and method development. New: Micro Reactor / Flow Chemistry scalable to production scale!

Qualified technical support and backup is available through operations in Japan, the United States (for the “Americas”), India, China and Germany (for Europe, Africa and the Middle East). www.ymc.de