Creates interactive maps of GPCR and kinase activity

Quickly reveals biological significance of data

Enhances communication; improves decision-making

Billerica, MA — EMD Millipore, the Life Science division of Merck KGaA* of Germany, today introduced the first software application for visualizing GPCR (G-protein coupled receptors), as well as kinase activity. The new Data Analysis and Report Tool (DART™), which can be accessed through EMD Millipore’s Drug Discovery portal, creates an interactive map of target profiling assay results and enables drug researchers to make faster, more informed decisions.

“Lead profiling often requires sifting through hundreds or even thousands of data points to pinpoint targets for further optimization studies,” said Paul Wilhite, Senior Manager of eBusiness at EMD Millipore. “This new online tool provides a unique, information-rich interface so scientists can rapidly narrow their research and effectively collaborate with colleagues.”

The application projects each compound’s activity profile onto a map depicting clusters of target protein families. This map provides scientists with immediate graphical insight into cross-target interactions to help drive structure-activity relationship (SAR) studies. The application is fully customizable. Data limits, sizing, colors, and target subclasses can be adjusted in seconds, thereby turning numerical data into a graphical display that can highlight biologically significant conclusions. Additionally, selected target information is dynamically populated and includes the gene symbol and aliases; links to bioinformatics content and recent publications; as well as links to appropriate EMD Millipore products.

“DART is the latest in the continuum of bioinformatics tools that EMD Millipore has launched in the past two years,” said Siamak Baharloo, Director of eBusiness at EMD Millipore. “We will continue our efforts to provide our customers with high-value experiment design and data analysis tools that empower their research.”

Clients of EMD Millipore’s KinaseProfiler™ and GPCRProfiler® screening services can upload their data directly into the DART tool or enter other datasets manually to take advantage of the software’s analytical power and presentation-quality images. For more examples of DART map views and compound profiles, visit www.millipore.com/visualize2.

ADDITIONAL RESOURCES

https://www.millipore.com/visualize2

ABOUT EMD MILLIPORE

EMD Millipore is the Life Science division of Merck KGaA of Germany and offers a broad range of innovative, performance products, services and business relationships that enable our customers’ success in research, development and production of biotech and pharmaceutical drug therapies. Through dedicated collaboration on new scientific and engineering insights, and as one of the top three R&D investors in the Life Science Tools industry, EMD Millipore serves as a strategic partner to customers and helps advance the promise of life science. Headquartered in Billerica, Massachusetts, the division has around 10,000 employees, operations in 64 countries and pro forma 2009 revenues of $2.9 billion. EMD Millipore is known as Merck Millipore outside of the U.S. and Canada.

Millipore and GPCRProfiler are registered trademarks and DART and KinaseProfiler are trademarks of Millipore Corporation.

*Merck KGaA or Merck shall mean Merck KGaA, Darmstadt, Germany