MELBOURNE, AUSTRALIA & HAYWARD, CALIFORNIA — Leica Biosystems

and Advanced Cell Diagnostics, Inc. (ACD) have announced the co-marketing of

ACD’s RNAscopeR LS ISH assays with Leica Biosystems’ BOND RX research

staining platform*. This agreement provides researchers with an integrated

and fully automated ISH solution. The market-leading RNAscope LS reagent

kits and ISH probes are available from ACD while the BOND RX instrument and

associated reagents are supplied by Leica Biosystems.

ACD’s RNAscope assays represent a major technological advance forin situ RNA

detection. For the first time,robust single RNA molecule detection is

available for formalin-fixed, paraffin-embedded (FFPE) tissue. Since their

commercialization three years ago, these assays have been adopted across the

globe by major pharma biotech companies and leading research institutions

for drug discovery, translational research, and the development of clinical

and companion diagnostic tests. The RNAscope LS assays are fully automated

on the BOND RX platform. This open and flexible system automates staining to

provide a fast, high throughput workflow with exceptional consistency and

minimal hands-on time.

“Automation is essential for pharmas, biotechs, translational labs and

academic institutions to apply the RNA ISH technology to a wide range of

biomarker analysis applications.” said Dr. Yuling Luo, President and CEO of

ACD. “We are very pleased to work with Leica Biosystems to expand our

automated RNAscope solutions in response to the needs of our rapidly growing

customer base.”

Dr.David Atkins, VP Advanced Staining at Leica Biosystems added: “Leica is

excited to announce the availability of ACD’s RNAscope Assays fully

automated on the BOND RX. This is another example of how,with its openness

and flexibility, the BOND RX is providing researchers with enhanced tools to

help speed-up important discoveries and improve cancer diagnostics”.

*For Research Use Only. Not for use in diagnostic procedures.

Learn more about ACD at www.acdbio.com and about RNAscope(R) Automated

Solutions at acdbio.com/products/automated-assays

Further information about Leica Biosytems can be found at

www.LeicaBiosystems.com.