The Thermo Scientific Cellomics Arrayscan VTI HCS Reader and the ZebraTox v3.0 BioApplication enable High Content Imaging and Analysis on Zebrafish Embryos

Baltimore, MD., (March 16, 2009) – Thermo Fisher Scientific Inc., the world leader in serving science, today announced the launch of the Thermo Scientific Cellomics ZebraTox v3.0 BioApplication at the SOT 48th Annual Meeting and ToxExpo from March 15-19 2009. This unique technique, coupled with the best in class ArrayScan VTI system, provides a new solution that automates the imaging and quantitation of zebrafish (D. rerio) embryos after a toxic insult. This introduction not only strengthens the Thermo Fisher Scientific portfolio of leading-edge High Content products for toxicology applications, but more importantly provides a tool to measure the gross effects of compounds in this important model organism

The new ZebraTox BioApplication assesses the size, shape and curvature of zebrafish embryos two or three days post fertilization and after a toxic insult. Configurable to use unlabelled or fluorescently labeled transgenic zebrafish embryos, the user can array the embryos in a 96 or 384 well format, then automatically image and quantitate features related to morphology, which are used to detect both gross and subtle changes in zebrafish development.

As a result of its ability to produce a high number of offspring along with its developmental and physiological similarity to mammals, the zebrafish embryo has become a widely-used model organism. Zebrafish promise to contribute to several aspects of the discovery process, including target identification, disease modeling, lead discovery and toxicity assessment by combining the scale and throughput of in vitro screens with the physiological complexity of in vivo animal studies, offering improved productivity for drug discovery, academic research and environmental toxicology studies.

This newly introduced ZebraTox BioApplication relies on the industry-leading Thermo Scientific Cellomics ArrayScan VTI system, which comprises HCS instrumentation, informatics and reagent products, allowing researchers to more rapidly test multiple compounds to discover potential effects on organism health and development. This application provides a unique, automated and less subjective, method for compound screening on organisms when compared to less sophisticated, traditional manual approaches.

The ZebraTox BioApplication, along with a selection of Thermo Scientific HCS products, can be seen at the Thermo Scientific booth #1663 at the Society of Toxiciology (SOT) Annual Meeting and ToxExpo, Baltimore, MD, March 15-19 2009.

For more information on the Thermo Scientific Cellomics range of products, please call 1-800-432-4091. Alternatively please visit www.thermo.com/cellomics.

Thermo Scientific is part of Thermo Fisher Scientific, the world leader in serving science.

About Thermo Fisher Scientific Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, enabling our customers to make the world healthier, cleaner and safer. With annual revenues of $10.5 billion, we have more than 34,000 employees and serve over 350,000 customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as environmental and industrial process control settings. Serving customers through two premier brands, Thermo Scientific and Fisher Scientific, we help solve analytical challenges from routine testing to complex research and discovery. Thermo Scientific offers customers a complete range of high-end analytical instruments as well as laboratory equipment, software, services, consumables and reagents to enable integrated laboratory workflow solutions. Fisher Scientific provides a complete portfolio of laboratory equipment, chemicals, supplies and services used in healthcare, scientific research, safety and education. Together, we offer the most convenient purchasing options to customers and continuously advance our technologies to accelerate the pace of scientific discovery, enhance value for customers and fuel growth for shareholders and employees alike. Visit www.thermofisher.com.