BioTrove Launches the OpenArray® DLP Real-Time qPCR Platform

BioTrove, Inc. today announced the launch of the OpenArray® DLP Real-Time qPCR platform, providing the first fully licensed high-density qPCR platform for use with customers’ TaqMan® chemistries. The launch is the latest addition to BioTrove’s real-time qPCR product offerings, rounding out the company’s suite of genomics research tools, which include custom OpenArray Real-Time qPCR panels using SYBR® chemistry and off-the-shelf OpenArray Pathways assay panels. Reinforcing BioTrove’s commitment to customer gene expression and pathogen detection research needs, this new product combines the data quality of TaqMan® chemistry with the higher-throughput, flexible OpenArray platform, delivering both labor and reagent savings.

The OpenArray DLP Real-Time qPCR platform provides a straightforward method for profiling miRNAs, detecting pathogens, validating microarray results and performing expression-based biomarker screens – applications evaluated, with significant success, by BioTrove’s broad animal and human health customer base. The combination of TaqMan® assays with OpenArray Real-Time qPCR genomic analysis enables better use of staff, reagent supply and resources, and boosts productivity.

“The OpenArray DLP platform enables researchers to complete projects in days instead of weeks, providing unprecedented gene coverage and sample throughput in a unique parallel-array format,” said Kevin Munnelly, vice president and general manager, BioTrove OpenArray Business Unit. “As the only fully licensed Real-Time qPCR instrumentation available at greater than 1536-wells, the OpenArray platform delivers superior technical capabilities on a much greater scale than other systems while ensuring that customer intellectual property remains protected, both now and in the future.”

Last year, Applied Biosystems (now Life Technologies, Inc.) and BioTrove, Inc. launched the TaqMan® OpenArray® Genotyping System for PCR-based SNP analysis, which is exclusively marketed by Life Technologies.

“Today’s launch, coupled with the existing success of the OpenArray platform for SNP genotyping research, speaks to BioTrove’s unmatched ability and commercial strength to deliver comprehensive genomics solutions in the custom high-density array market,” said Albert A. Luderer, Ph.D., President and CEO, BioTrove. “Now, the research community will have access to the only fully licensed high-density platform for Real-Time qPCR, enabling them to complete projects faster, and more importantly, ask new questions and feel secure with the answers.”

The new OpenArray DLP system accelerates genomic discovery and validation, pathogen detection, as well as biomarker identification and screening, at a scale previously unattainable using TaqMan® chemistry. BioTrove will be present and available to discuss its OpenArray technology at the qPCR 2009 conference in Freising, Germany, March 9-13, and the Quantitative PCR conference in San Diego, CA, March 16-17.

About PCR and TaqMan®

PCR is a standard technique used in life sciences settings. In real-time qPCR, the sample DNA or cDNA is quantified during the PCR process by measuring the kinetics of the reaction, rather than at the end of the reaction, facilitating greater accuracy in important applications such as gene expression quantification.

The OpenArray platform is available in a full range of genomics research products, including the catalog of OpenArray Pathways qPCR panels, OpenArray Real-Time qPCR customizable panels using SYBR® chemistry and the new OpenArray DLP Real-Time qPCR customizable panels. For more information on the OpenArray DLP Real-Time qPCR system using TaqMan® chemistry, visit www.BioTrove.com/DLP.

TaqMan® is a registered trademark of Roche Molecular Systems, Inc. SYBR® is a registered trademark of Molecular Probes, Inc.

About BioTrove, Inc.

BioTrove, Inc. offers two innovative technology platforms: OpenArray®, which advances genomic research in a wide range of life science fields, including agriculture, disease research, and public health, and RapidFire®, which enables the acceleration of drug discovery and pipeline decisions. With 11 of the 15 largest biopharmaceutical companies based on global sales as clients, and partnerships with prestigious research and public health centers around the world, BioTrove’s products and services ensure that an industry committed to accuracy and speed can meet business goals.

The OpenArray® Platform enables genomics researchers to generate SNP and real time qPCR data in the hundreds of thousands of data points per day, significantly increasing the number of samples analyzed while significantly decreasing the time and cost required. The flexible format and nanoliter scale of the OpenArray system allows for easy adjustment of sample and assay numbers, achieving economical, high-throughput genomics. Life Technologies globally markets the OpenArray SNP genotyping platform under the TaqMan® OpenArray® SNP Genotyping brand. BioTrove is a licensee of Life Technologies global patent rights related to the real-time thermal cyclers, microfluidics and data analysis.

RapidFire® Mass Spectrometry (RF-MS) feeds samples directly to the mass spectrometer at six to eight seconds per sample, eliminating the bottleneck created by traditional mass spectrometry throughput. RF-MS is routinely used in many applications including the high-throughput screening of previously intractable drug targets, ADME assays and directed evolution studies.

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