SANTA ANA, California — Irvine Scientific, a strategic manufacturer of cell culture media,

announced today the expansion of their cell therapy product portfolio with the launch of new media and recombinant

growth factors. The product line is designed to provide an integrated workflow solution for the culture of human stem

cells and primary cells. In addition to the existing PRIME-XVTM MSC Expansion SFM medium, intended for the

expansion of human mesenchymal stem cells, Irvine Scientific is introducing three new media. These new

formulations are used for neural progenitor cell (NPC) expansion, amniotic fluid stem cell (AFSC) expansion and

tumorsphere formation. To facilitate clinical applications, these media are manufactured in an ISO13485 certified

facility and have pending Drug Master Files.

“A major hurdle in using stem cells and primary cells for developing therapeutic applications is the ability to generate

sufficient quantities of functional cells of the targeted type,” says Dr. Jessie Ni, Chief Scientific Officer at Irvine

Scientific. “That’s why our main goal when developing new products is to provide high performing media that

maximizes cell growth and maintains desired cell function.”

PRIME-XVTM Amniotic Fluid Stem Cell Expansion Medium represents one of the first commercially available expansion

media for extended human AFSC culture.

PRIME-XVTM Neural Progenitor Expansion Xeno-Free, Serum-Free Medium is designed to optimally expand human

NPCs in neurospheres and monolayers.

PRIME-XVTM Tumorsphere Serum-Free Medium is validated for the formation of tumorspheres from various human

tumor cell lines.

Additionally, Irvine Scientific offers animal component-free, recombinant human growth factors such as Activin A,

FGF-basic 154, and GM-CSF.

©2013 Irvine Scientific P/N 10478CT Rev.1

About Irvine Scientific

Irvine Scientific, a member of JX group, is a worldwide leader in the design, manufacture and distribution of medical

devices, including Cell Therapy, Industrial Cell Culture, Cytogenetic, and Assisted Reproductive Technology (ART)

products. Irvine Scientific is a worldwide media provider that is regulated and adheres to both ISO and FDA regulations

with dual manufacturing facilities in California, USA and Tokyo, Japan. Irvine Scientific is a large scale producer of

advanced quality cell culture media for the industrial bioprocess, medical, and diagnostic markets. The company’s

extensive experience in the design of culture media, compliance with ISO and FDA regulations for class II / III medical

devices, and industrial scale manufacturing capacity provides customers with unique capabilities and support.

About Irvine Scientific

2511 Daimler Street, Santa Ana, CA 92705-5588

800 437 5706 ? 949 261 7800 ? Fax: 949 261 6522

www.irvinesci.com

Date: November 19, 2013

Contact: Ms. Makenzie Carter

Phone: 949-261-7800 x202

Email: mcarter@irvinesci.com