Cambridge, United Kingdom – Leading scientists at Takeda Pharmaceutical Company conducted groundbreaking quality control research of layer separation of pharmaceutical tablets using Terahertz Pulsed Imaging (TPI™). Data collection and findings are based on their use of TeraView’s TPI imaga 2000 system and are published in the International Journal of Pharmaceutics.

The research, Quantitative analysis of the layer separation risk in bilayer tablets using terahertz pulsed imaging, compares Terahertz Pulsed Imaging technique to other analytical methods and has determined that “TPI can aid in quality control by providing a precise estimate of the layer separation risk and robust quality of bilayer tablet development with better understanding of layer separation”.

In recent months, Terahertz Pulsed Imaging has received significant attention from the pharmaceutical research community with papers focusing the attention on the use of technique in the measurement and quality control of pharmaceutical coatings. TPI™ provides the ability to non-destructively and rapidly analyze the coating layer thickness and quality of coated pharmaceutical tablets and other solid dosage forms. Because it is non-destructive, tablets can be re-examined at later times to monitor coating stability or used for further functional studies with prior knowledge of the coating uniformity. Some of the recent papers include:

Critical factors in the measurement of tablet film coatings using terahertz pulsed imaging

Hardness and density distributions of pharmaceutical tablets measured by terahertz pulsed imaging

Terahertz pulsed imaging as an advanced characterisation tool for film coatings—A review

For a full list of papers please visit our publications page. If you would like to learn more about the technique and how it can help in your product development area, please get in touch at enquiries@teraview.com.

About TeraView

TeraView is the world’s first company devoted to the application of Terahertz light for spectroscopy and imaging. A spin out from Toshiba and University of Cambridge in 2001 and employing circa 25 staff, TeraView has been developing the technology across a number of areas/applications and now has equipment in over 20 countries. Headquartered in Cambridge, UK sales and support are available throughout Europe, North America and Asia Pacific either directly or through a network of distributors.