MILPITAS, Calif. — Deoxyribonuclease I (DNAse I) is an endonuclease that cleaves DNA phosphodiester bonds. DNAse I targets single-stranded DNA, double-stranded DNA, and chromatin in a non-specific manner.  Abnormal DNAse I activity occurs in association with a variety of cancers and auto-immune diseases that exhibit elevated levels of cell-free DNA. BioVision’s DNAse I Activity Fluorometric Assay Kit allows for quantitative evaluation of DNAse I activity of purified enzymes and their inhibitors as well as comparative examination of DNAse I activity in biological samples. Enzyme activity is directly detected upon cleavage of a DNA Probe, which yields a fluorescent DNA product. Our assay kit is simple (does not require antibodies or PCR tools), sensitive, specific and validated with human serum.
Key Features:
• Simple: Direct measurement of DNAse (Enzyme-based principle)
• Non-radioactive
• Specific, homogeneous assays
• Accurate: reproducible results
• Convenient: minimal sample preparation; fast protocols (1-2 hours )
• Cost effective: 100 assays; High Throughput Screening compatible
• High-Throughput Compatible

Figure: (A) Representative activity curves for purified DNAse I (orange), serum sample (green), and background control (blue) at 37°C; B) comparative analysis of DNAse I activity from 25 µl undiluted single donor normal vs. Systematic Lupus Erythematosus (SLE) patient serum sample.

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