On January 4, 2021, Analytical BioSciences, a single-cell genomics and discovery company, launched OmniBrowser™, a comprehensively curated single cell data compendium with visualization and analysis capabilities that further empower innovative drug discovery and development.

“Single cell genomics is becoming a cornerstone for drug discovery and development, clinical diagnosis and scientific research. I hope that OmniBrowser™ brings more insights to researchers in pharmaceutical companies, universities and other research institutions, helping them make great progress in their research efforts.” said Professor Zemin Zhang of Peking University, founder and a scientific advisor of Analytical BioSciences.

“With the single-cell genomic revolution, astronomical amount of data had been generated and continue expanding,” said Dr. Yangzhou Wang, CEO of Analytical BioSciences. “To harness the true value of those data, a unified platform that systematically integrate single cell data from all possible sources becomes not just desirable but necessary. The Analytical Biosciences’ OmniBrowser™ is our answer to that challenge. With the OmniBrowser™, an updated and comprehensive collection of curated and integrated single cell datasets can be systematically and efficiently queried, compared, and visualized. Our goal is to empower scientists all over the world to take full advantage of this data deluge and expedite their efforts in target identification and validation, biomarker discovery, as well as in other biological and clinical research.”

OmniBrowser™ is a web portal for scRNA-seq data exploration, supported by a spectrum of commonly used tools for data visualization and analysis. The OmniBrowser™ toolset is designed with a special attention to support biologists with limited programming and analytical bandwidth or depth. With OmniBrowser™, the barrier to extract insight and value from the voluminous single cell space will be greatly reduced for bioinformaticians and laboratory researchers.

The underlying database of OmniBrowser™, Omni Single Cell Database, is currently the largest curated scRNA-seq dataset collection in the world, with：
>1490 datasets
>680 studies
>18k clusters
>21M cells

To efficient access such a huge collection of data, OmniBrowse provides a series of web-based tools for:
1 Dataset Selection: datasets searching and customized filtering
2 Dimensional Reduction: datasets visualization with 2D/3D t-SNE&UMAP or PAGA
3 Differential Expression: display of differential expression of genes via Box plot & violin plot & Heatmap
4 Correlation Analysis: the correlation of two sets of genes by scatter plot/heatmap; searching for most similar genes
5 Marker Gene: display of marker gene information and accompanying statistics
6 GO Analysis: display of GO enrichment results
7 Supervised Annotation: annotation of cell types by SciBet and display of results by bar plot & Sankey diagrams
8 Metadata Analysis: analysis of relationships between multiple cell-level and sample-level metadata annotations, display by bar plot

In addition，OmniBrowser™provides multiple large scale data processing functions, including:
1 Gene Search: display of specific gene’s expression in all/filtered datasets
2 Cell Ontology: search of dataset by specific cell types

Furthermore, OmniBrowser™provides analysis and visualization of integrated datasets from multiple normal tissue datasets.

“Thanks to the new algorithms developed by our brilliant engineers, OmniBrowser™ can simultaneouslyload and process genomic and other data from millions of cells within seconds, ” said Dr. Yuelan Wang, head of the Bioinformatics Software Department and a Vice President of Analytical BioSciences. “Its superior performance when dealing with large datasets in single-cell data processing highlights the depth and the breadth of Analytical Biosciences in the single cell domain.”

Several pharmaceuticals companies have already incorporated OmniBrowser™ into their internal drug R&D process as the early-access users of the product. “By taking into account the need to maintain data confidentiality of pharmaceutical companies, OmniBrowser™ can also be deployed as a dedicated web portal and/or a local server deployment inside a pharma’s firewall.” said Yuelan Wang.

Datasets are constantly updated on OmniBrowser™, as are the analytical functions, in order to support the ever-growing demands from a wide range of customers. As datasets and analytical functions continue to expand on the OmniBrowser™ platform, Analytical Biosciences will develop and distribute more collection of tools that will make the analyses of big data more efficient and effective in order to advance the biomedical R&D.

Now, OmniBrowser™ is open for registration, the free trial version provides 5 datasets with full function. For more information, please visit https://omnibrowser.abiosciences.com/

About

Analytical BioSciences is a leader in single cell genomics. Our mission is to unlock the mechanism of diseases through the most advanced translational single cell platforms with the largest, high-resolution databases, and the most comprehensive commercial grade data analytics. Led by science and data, we generate new knowledge and compile insights for the identification and validation of novel cellular targets and biomarkers, which ultimately lead to next generation breakthrough therapeutics and diagnostics.