• PODS-PeptiGels combine two stand-out technologies in single customisable cell culture environment
• Provides researchers with a predictable and controlled system, with potential for long-term experiments and reduced hands-on time

Cambridge and Manchester, UK: Cell Guidance Systems Ltd, a specialist in the control, manipulation, and monitoring of cells, both in vitro and in vivo, and Manchester BIOGEL, a biotechnology company specialising in the design and manufacture of 3D synthetic peptide hydrogels, today announced a collaboration to launch PODS^®-PeptiGels^®. The new kit combines the benefits of two existing innovative cell culture technologies – synthetic peptide hydrogels (PeptiGels) and a range of sustained release growth factors (PODS) – to provide a reproducible and highly adaptable environment for 3D cell culture.

PODS-PeptiGels incorporates Cell Guidance Systems’ POlyhedrin Delivery System (PODS) and Manchester BioGel’s biologically relevant hydrogels (PeptiGels). The ready-to-use kit allows researchers to mix and match to suit the aims of their research by selecting from more than 70 growth factors and combining with hundreds of combinations of hydrogels, each with mechanical and biomimetic tuneability.

Providing researchers with an all-in-one, animal free, solution for 3D cell culture applications, the PeptiGel hydrogel, available in a variety of gel stiffness and cell adhesion motifs, is produced using synthetic peptides reducing batch variations and enables reproducible results. The PODS crystal protects the growth factor cargo allowing sustained release over a longer period, thereby reducing the frequency of media changes required and minimising growth factor concentration cycles.

Dr Michael Jones, CEO of Cell Guidance Systems, commented: “We are excited to launch PODS-PeptiGels with Manchester BIOGEL. Combining the benefits of PeptiGel and PODS technologies provides researchers with a simple and repeatable, physiologically relevant, cell matrix that produces consistent results in addition to reducing hands-on time.”

Dr Donald Daley, CEO of Manchester BIOGEL, said: “Batch-to-batch variation of hydrogels is a big issue and our synthetic PeptiGels overcome this by eliminating variation making it easier to compare results. PeptiGels are functionalised synthetic platforms that support cell growth and are also free from animal origin. This combined with recombinant growth factors that do not degrade quickly due to the PODS technology from Cell Guidance Systems, makes for a powerful 3D cell culture solution that can be scaled up to high throughput, if required, whilst producing consistent and accurate results.”

For further information about Cell Guidance Systems’ PODS technology, please visit: https://www.cellgs.com/pods-technology.htm

For further information about Manchester BIOGEL’s peptide hydrogel technology, please visit: https://manchesterbiogel.com/mbg-core-technology/

About Cell Guidance Systems www.cellgs.com

Cell Guidance Systems is a private biotechnology company providing products and services for life science research and was founded to enable control and manipulation of cells, both in-vitro and in-vivo. Cell Guidance Systems has been developing the PODS platform for research and therapeutic applications. The Company’s products are highly cited, and it has established a reputation for innovation, quality, and high service levels. A wide range of PODS-cytokines are available to the research community via the website. For further information, contact info@cellgs.com.

Follow Cell Guidance Systems on LinkedIn @cell-guidance-systems and Twitter @CellGuidance

About Manchester BIOGEL https://manchesterbiogel.com/

Manchester BIOGEL is a global leader in the design and manufacture of synthetic self-assembling peptide hydrogels that provide a natural physiological extracellular matrix to support long term culture. Their biologically relevant hydrogels mimic the cell micro-environment and their stiffness and functionality can be modulated to simulate the natural environment of all human tissues. Manchester BIOGEL’s proprietary technology is 100% ethical, animal free and chemically defined. It opens up opportunities and offers clinically translatable solutions to meet current healthcare challenges within the growing fields of 3D cell culture, 3D bioprinting, tissue regeneration and drug discovery. For further information, contact pr@manchesterbiogel.com.

Follow Manchester BIOGEL on LinkedIn @mancbiogel and Twitter @MancBIOGEL