Collaboration delivers an automated, high-plex molecular testing workflow on Hamilton liquid handling workstations

Bonaduz, Switzerland / Stockholm, Sweden – Hamilton and Aplex Bio today announced a co-marketing agreement to jointly promote an automated liquid handling solution for Aplex Bio’s Hyperplex PCR™ (hpPCR™) Assay Kits on Hamilton robotic platforms. The collaboration enables highly automated detection and quantification of up to 100 molecular markers in a single well, combining exceptional specificity, ultra-sensitive performance, and scalable laboratory automation.

Molecular analysis is at a pivotal point, as conventional PCR workflows can become impractical or cost-prohibitive for high-throughput applications requiring broad genomic insight or precise quantification of numerous, difficult target sequences within a single sample. While next-generation sequencing (NGS) excels at discovering novel genes and provides exceptional sequence specificity, ongoing reagent costs, service fees, training requirements, and turnaround times continue to limit accessibility for many laboratories.

To address these challenges, laboratories increasingly require automated molecular testing solutions that can reliably and rapidly detect multiple low-abundance targets at scale, integrate seamlessly into existing workflows, and avoid rising cost per sample as multiplexing and analytical breadth increase.

Hyperplex PCR is a molecular counting technology powered by Nanopixels™, padlock probes, and rolling circle amplification–based digital assays. Together, these technologies enable single-nucleotide resolution, ultra-high sensitivity, and high-plex capability, delivering same-day, precise quantification of up to 100 targets per well. Combined with Hamilton’s expertise in laboratory automation and protocol optimization, the partnership enhances the scalability, reproducibility, and data integrity of the Hyperplex PCR platform.

“Hamilton strives to partner with global leaders in their respective fields, making Aplex Bio and its innovative technology a perfect fit,” said Roberto Fantozzi, Director Commercial Excellence “The partnership allows researchers fast access to a highly automated workflow that speeds up processing time and improves data integrity.”

“We are very pleased to partner with Hamilton, a global leader in automation,” said Umear Naseem, CEO of Aplex Bio. “Hyperplex PCR was built to integrate seamlessly with existing laboratory environments by being SBS-compatible, automation-ready, and deployable without new infrastructure. Integrating hpPCR with Hamilton’s systems extends this vision, enabling rapid scalability and providing laboratories with immediate access to high-precision, high-plex testing in a sample-to-answer workflow. This collaboration supports our broader vision of making comprehensive molecular measurement both accessible and routine across a wide range of applications.”

Aplex Bio is at the forefront of advanced molecular testing, delivering platform technologies that expand capabilities in precision genomics, molecular diagnostics, and high-frequency biological screening. Hyperplex PCR™, the company’s next-generation platform, introduces a new paradigm in molecular measurement by combining multiplexed detection, molecular counting, and single-nucleotide discrimination in a single workflow. The platform delivers digital-like single-copy sensitivity while scaling to 100+ targets per well, addressing limitations in plex, precision, and cost-efficiency that constrain both traditional PCR and sequencing technologies. Aplex Bio is dedicated to advancing the next generation of molecular diagnostics and enabling technologies for population-scale applications that can contribute to improved healthcare outcomes worldwide. The company is headquartered in Stockholm, Sweden.

Hamilton For more than 75 years, Hamilton Company has been a global life sciences leader in the design and manufacturing of precision measurement devices, automated liquid handling platforms, and sample management solutions. Headquartered in Reno, Nevada, with key manufacturing and R&D affiliates in Bonaduz, Switzerland, Franklin, Massachusetts, and Timisoara, Romania, Hamilton serves the scientific community through a robust network of sales and support offices worldwide.

Hamilton’s expertise spans across liquid handling, process analytics, robotics, and automated storage, providing the foundational tools necessary for groundbreaking scientific research and clinical discovery. By combining the best-quality materials with skilled workmanship and a lifelong commitment to ISO 9001-certified precision, Hamilton ensures the highest level of performance and reliability. Hamilton remains dedicated to driving innovation and satisfying the evolving needs of laboratories across the globe, maintaining a steadfast focus on quality and customer success.