MS & LC/MS
Company Announcements
Elementar announced in September that its Japanese isotope-ratio MS customers will now be directly supported by the company. These customers were previously supported by JASCO.
In September, proteomics CRO and product provider MRM Proteomics partnered with nonprofit Exactis Innovation to develop and validate a clinical proteomic test to identify immune signatures and tumor mutation profiles to better match patients with the most effective treatments. The company calls the test the first immuno-MALDI test to measure the activity of multiple cancer-associated proteins in patients’ tumors.
Thermo Fisher Scientific announced in September its intent to open multiple Global Customer Solution Centers serving food, beverage, pharmaceutical and biotechnology laboratories, by developing critical workflows and integrated solutions that help advance chromatography and MS. One collaboration will be between the Dehli, India-based Center and the Food Safety and Standards Authority of India. The inaugural phase of the new global strategic initiative will be marked by multiple Customer Solution Center openings in locations across the world including India and China, followed by additional centers in the US and Europe.
In October, Thermo Fisher Scientific entered into a two-year collaboration with Symphogen, an oncology-focused clinical-stage antibody company, to deliver validated, platform workflows for simplified characterization and quality monitoring of complex therapeutic proteins. It builds upon a decade-long relationship. Symphogen will use the Thermo Scientific Q Exactive Plus Orbitrap LC-MS/MS system. The collaboration will feature an additional focus on the development of automated multi-attribute method workflows for monitoring critical quality attributes of proteins using high-resolution accurate-mass MS in a QC environment.
In October, Bruker expanded its relationship with Bioinformatics Solutions, developer of PEAKS software, to include reselling. PEAKS can efficiently analyze timsTOF Pro data for ID, label-free quantitation, and quantitation with isotopic labeling such as TMT, iTRAQ and SILAC. PEAKS can now also use all four dimensions of timsTOF Pro data to deconvolute spectra from species that overlap in two or more dimensions.
In October, IonSense announced that its collaboration with Cayman Chemical has resulted in a validated mass spectral database of one thousand compounds for the rapid screening of drugs of abuse using Direct Analysis in Real Time (DART) MS.
Agena Bioscience and DaRui Biotechnology announced in October the formal registration of Agena Bioscience’s AgeMassARRAY with the Guangdon Food and Drug Administration, stating it is the first China FDA-approved MALDI-TOF MS system to directly detect nucleic acids for IVD in China. It is commercially branded in China as the DR MassARRAY.
Product Introductions
In September, Thermo Fisher Scientific launched the Thermo Scientific VetDrugs Explorer Collection, a single-provider LC/MS/MS-based solution for quantitation of multi-residue veterinary drugs in complex animal-derived sample matrices. The Collection, which includes a QuEChERS kit, LC column, LC/MS/MS, triple quadrupole MS and compound database, can currently meet current regulatory standards of more than 160 veterinary drugs in analytically challenging sample matrices.
Thermo Fisher Scientific introduced in September the Thermo Scientific ISQ EM single quadrupole MS system, featuring a mass range of 10–2000 m/z. The system’s heated electrospray ionization (HESI) and dual HESI/APC probes facilitate the measurement of polar and non-polar analytes, enabling application flexibility.
In October, Bruker introduced updates to its timsTOF Pro system, including large-scale, reproducible, accurate collision cross section (CCS) values for tryptic peptides and a CCS-based lipidomics workflow that includes CCS prediction using machine learning. The new FastPro method enables higher peptide and protein group ID rates with better sequence coverage and enhanced detection of post translational modifications.
Waters introduced in October the RenataDx Screening System, a flow-injection tandem MS (FIAMS-MS) system for clinical research labs. It provides rapid high-throughput analysis of extracted dried blood spots and other human biological matrices. It can run any suitable FIAMS/MS LDT or ready-to-use reagent kit. The System consists of the Xevo TQD IVD MaMS, the ACQUITY UPLC I-Class IVD Binary Solvent Manager and the 3777C IVD Sample Manager. The RenataDX Screening System is manufactured as an US FDA Class I medical device and is CE marked.
908 Devices added in October a novel predictive fentanyl classifier to its MX908 multi-mission trace chemical detection device. The classifier can recognize the molecular structure of more than two thousand previously undetectable fentanyl analogs.
