10x Genomics Expands Leadership in Single Cell Analysis with Launch of GEM-X Technology

GEM-X, the next generation of the company’s leading single cell technology architecture, enables higher performance at larger scale and lower cost

Pre-orders now open for first two Chromium products powered by GEM-X; expected to ship in Q1

PLEASANTON, Calif. — 10x Genomics, Inc. (Nasdaq: TXG), a leader in single cell and spatial biology, announced today the launch of GEM-X, the next generation of the company’s leading single cell technology. The first major overhaul to the Chromium architecture since the 2019 launch of Next GEM technology, GEM-X is built on a new and improved microfluidic chip design, featuring the latest technological advancements and optimized reagents for superior performance and high reliability.

“With GEM-X, we are advancing our leadership in single cell analysis, raising the bar on performance and setting a new standard for the field,” said Michael Schnall-Levin, Founding Scientist and Chief Technology Officer of 10x Genomics. “This is a game-changing technology that will help drive better, faster and more cost effective single cell research and enable more academic and translational researchers to routinely rely on these tools to help resolve biology’s complexity.”

The company is now accepting preorders for the first two product launches powered by the GEM-X technology architecture, Chromium Single Cell Gene Expression 3’v4 and Chromium Single Cell Immune Profiling 5’v3. These assays are expected to begin shipping this quarter.

The new GEM-X technology offers significant performance advantages, including:

  • Substantially increased sensitivity: Detect up to two times more genes compared to on-market Chromium assays to gain a more comprehensive view of cellular heterogeneity
  • Built to scale: Two-fold increase in cells captured per channel
  • More cost effective: More than two-fold reduction in cost per cell
  • Enhanced data quality: Two-fold reduction in multiplet rate enabling high quality data at scale
  • Maximum sample recovery: Recovery of up to 80% of cells, improving capture efficiency and making it ideal for samples typically yielding few cells, such as tissue biopsies or previously flow sorted cells
  • Improved assay robustness: Redesigned microfluidics and optimized reagents for faster and more efficient cell partitioning

“This is just the beginning for GEM-X and for single cell analysis,” added Schnall-Levin. “We have a robust GEM-X roadmap ahead, including a comprehensive menu of high performance assays and applications with the economics to drive broad adoption and large scale.”

GEM-X is exclusively available for use on Chromium X Series instruments.

About 10x Genomics
10x Genomics is a life science technology company building products to accelerate the mastery of biology and advance human health. Our integrated solutions include instruments, consumables and software for single cell and spatial biology, which help academic and translational researchers and biopharmaceutical companies understand biological systems at a resolution and scale that matches the complexity of biology. Our products are behind breakthroughs in oncology, immunology, neuroscience and more, fueling powerful discoveries that are transforming the world’s understanding of health and disease. To learn more, visit 10xgenomics.com or connect with us on LinkedIn or X (Twitter).

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