10x Genomics Launches Visium CytAssist Gene and Protein Expression Assay

Combining tissue profiling with whole transcriptome spatial analysis and high-plex protein co-detection enables a deeper, more holistic understanding of tissue organization

PLEASANTON, Calif. — 10x Genomics, Inc. (Nasdaq: TXG), a leader in single cell and spatial biology, announced today the commercial availability of a new Visium CytAssist Gene and Protein Expression product to expand the breadth of the Visium CytAssist spatial analysis capabilities.

“The continued expansion of our Visium platform is a testament to the strength of our innovation engine and demonstrated leadership in spatial biology,” said Michael Schnall-Levin, Founding Scientist and Chief Technology Officer. “This launch complements our focus on multiomic analysis and broader protein capabilities on all three of our leading platforms, including single cell and in situ analysis.”

Visium CytAssist Gene and Protein Expression enables researchers to simultaneously produce highly multiplexed protein and whole transcriptome RNA data mapped together from the same formalin-fixed, paraffin-embedded (FFPE) tissue section at high spatial resolution. The Human Immune Cell Profiling Panel is an optimized, pre-titrated solution that enables the detection of 31 intracellular and extracellular proteins and includes isotype controls for in-line normalization.

Visium’s unique morphology-first workflow allows for H&E staining upstream of chemical treatments made to the tissue section. This allows researchers to study the morphology of their tissue on the same section they also use for deeper spatial multiomic exploration, allowing for three dimensions of spatial analysis on the exact same sample.

“We are excited to leverage the CytAssist Gene and Protein Expression solution to generate more complete assessments of protein, RNA, and morphology together on each and every tissue section,” said Dr. David Gate, Assistant Professor of Neurology at Northwestern University. “Spatial transcriptomics with immune cell profiling at the protein level is transforming our understanding of complex biological processes in neurodegenerative disease with great potential to provide new insights into Alzheimer’s disease pathology.”

About CytAssist Gene and Protein Expression
Visium CytAssist Gene and Protein Expression enables combined capture of protein and whole transcriptome gene expression simultaneously with histological analysis in one experiment, from a single tissue section, using a sequencing based readout. The new kit, which is exclusively available for use with Visium CytAssist, is now shipping.

Visium CytAssist is a compact, benchtop system designed to enable the rapid transfer of transcriptomic probes from tissues on standard microscope slides to Visium slides. The instrument, launched in 2022, streamlines the Visium workflow by allowing expanded sample access, simplifying sample handling and improving data quality for spatial transcriptomic studies.

About 10x Genomics
10x Genomics is a life science technology company building products to interrogate, understand and master biology to advance human health. Our integrated solutions include instruments, consumables and software for analyzing biological systems at a resolution and scale that matches the complexity of biology. 10x Genomics products have been adopted by researchers around the world including in all of the top 100 global research institutions as ranked by Nature in 2021 based on publications and all of the top 20 global pharmaceutical companies by 2021 research and development spend and have been cited in over 5,000 research papers on discoveries ranging from oncology to immunology and neuroscience. Our patent portfolio comprises more than 1,750 issued patents and patent applications.

Forward Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 as contained in Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are subject to the “safe harbor” created by those sections. All statements, other than statements of historical facts, may be forward-looking statements. Forward-looking statements generally can be identified by the use of forward-looking terminology such as “may,” “might,” “will,””enable,” “should,” “expect,” “plan,” “anticipate,” “could,” “intend,” “target,” “project,” “contemplate,” “believe,” “estimate,” “predict,” “potential,” “would,” “likely,” “seek” or “continue” or the negatives of these terms or variations of them or similar terminology, but the absence of these words does not mean that a statement is not forward-looking. These forward-looking statements include statements regarding 10x Genomics, Inc.’s expectations regarding the continued expansion of our Visium platform and our product momentum and progress, including the performance of Visium’s unique morphology-first workflow. These statements are based on management’s current expectations, forecasts, beliefs, assumptions and information currently available to management, and actual outcomes and results could differ materially from these statements due to a number of factors. The material risks and uncertainties that could affect 10x Genomics, Inc.’s financial and operating results and cause actual results to differ materially from those indicated by the forward-looking statements made in this press release include those discussed under the captions “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operations” in the company’s most recently-filed 10-K and elsewhere in the documents 10x Genomics, Inc. files with the Securities and Exchange Commission from time to time.

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