3M Harvest RC Chromatographic Clarifier Now Available Through Thermo Fisher Scientific

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Overview:

 

The 3M Harvest RC Chromatographic Clarifier, a single-stage harvest solution, is now commercially available to therapeutic developers and manufacturers through Thermo Fisher Scientific. The 3M technology is complementary to Thermo Scientific single-use bioreactors (S.U.B.s), such as the recently launched Thermo Scientific DynaDrive S.U.B. and the well-established HyPerforma S.U.B. 

 

Pharmaceutical and biotech companies face challenges harvesting cell culture fluid consistently and at scale for developing drugs such as monoclonal antibody (mAb) therapies. By employing synthetic fibrous AEX chromatographic clarification media, the 3M Harvest RC enables single-stage clarification of low- to high-density Chinese Hamster Ovary CHO cell cultures (>40 million cells per mL) with high product recovery. The clarifier also reduces traditional filtration processes into a single step.

 

Key Applications:

Therapeutic development using CHO cells where there is a need for scalability, performance and cost reduction.

 

Features/

Benefits:
  • Increased mAb yields: 3M Harvest RC chromatographic clarification capsules consistently provide >95% mAb product recovery for high cell density cultures.
  • Scalability: 3M Harvest RC capsules scale linearly to meet laboratory, pilot, and manufacturing needs. 
  • Consistent cell loading capacity: Advanced Q functionalized fibrous chromatography media enables single-stage clarification of CHO cell culture fluid, helping users achieve predictable cell loading capacity for a wide range of packed cell volumes.
  • Low cell shearing: Low-pressure chromatographic clarification relies on charge rather than size or density for minimal cell shear compared to conventional depth filtration processes, even at medium and high cell densities. 
  • Robust sterile filter protection: Highly effective chromatographic reduction of soluble and insoluble contaminants enables efficient clarification and effective protection of final sterilizing grade membrane filter down to 0.1 μm pore size.

Web Site:

 

 

About Thermo Fisher Scientific  

Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of approximately $35 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, improving patient diagnostics and therapies or increasing productivity in their laboratories, we are here to support them. Our global team of more than 90,000 colleagues delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services and Patheon. For more information, please visit www.thermofisher.com.

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