South Easton, MA – Pressure BioSciences, Inc. (NASDAQ: PBIO) (“PBI” and the “Company”) today announced that leading, independent researchers from academia, government, pharma, and the biotechnology industry have reported significant advantages when using the Company’s novel and enabling pressure cycling technology (“PCT”) platform in their critical sample preparation processes. The presentations were made at several major scientific conferences. The studies involved such importantareas as biomarker discovery, therapeutics, and vaccine development.

Dr. Nathan Lawrence, Vice President of Marketing for PBI, said: “We believe that PCT is a powerful technology platform that can be of meaningful value to thousands of research laboratories worldwide. Specifically, we believe that the incorporation of PCT into the sample preparation workflow of many of these laboratories can result in faster sample processing, improved quality, and a reduction in cost.”

Dr. Lawrence continued: “The number of presentations and publications from independent scientists citing the use and advantages of PCT is increasing, as are the number and frequency of unsolicited calls for information and price quotations. We believe this is not only a strong indication of increasing market awareness, but the beginning of market acceptance as well. We further believe that this early market acceptance will manifest itself in increased revenue over both the short and long term.”

Mr. Richard T. Schumacher, President and CEO of PBI, said: “As per guidance previously given, we continue to believe that PCT Products revenue for Q3 2011 will exceed PCT Products revenue for any quarter over the past year, and that total revenue for the second half of 2011 will be significantly greater than total revenue for the first half of 2011. We are in active discussions with several companies about regional and worldwide distribution of our product line. We remain on track to release our PCT-based FFPE service in late 2012. We also continue to make progress in the development of our XstreamPCT™ HPLC Digestion Module and our high throughput micro-well Barocycler System; we expect to release both new instrument systems by late 2013.”

Mr. Schumacher concluded: “We believe that our PCT-based instruments and consumables fill a major market need for a better, faster, more accurate, and more versatile sample preparation system, particularly in the important area of protein research. We also believe that we need a more active and aggressive sales and marketing approach to successfully introduce the advantages of the PCT Platform to significantly more researchers than are aware of PCT today. To that end, we remain optimistic that we will raise the capital necessary to support our continued operations and future growth, including the development and support of a more aggressive, broad-based sales and marketing program.”

Several of the conferences where scientists presented on the use and significant advantages of PCT are listed below; additional venues and presentations can be found at www.pressurebiosciences.com.

American Society for Mass Spectrometry (ASMS) Annual Meeting

Presenting scientists were from Pacific Northwest National Laboratory, DOE (Richland, WA); FDA-CFSAN (College Park, MD); Merck Research Laboratories (West Point, PA); and Centocor R&D, a division of J&J PRD (Radnor, PA).

Data were presented on the use of PCT to rapidly, effectively, and efficiently characterize certain proteins used in the development of bio-therapeutic drugs (we believe there are hundreds of such drugs in the pipeline); to be the driving force behind an automated, in-line, on-demand high throughput protein digestion module (we believe this instrument will save significant time and money, compared to current methods); to help in the identification of strain specific bacterial markers; to help identify new proteins of interest as potential vaccine targets; and to significantly reduce the time required for the characterization of monoclonal antibodies (bio-therapeutics), with a concomitant increase in quality.

2011 Meeting of the European High Pressure Research Group (EHPRG 2011)

Presenting scientists were from the Barnett Institute of Northeastern University (Boston, MA); the University of Debrecen (Hungary); and the University of Massachusetts (Boston, MA).

Data were presented on the significant advantages of PCT in the analysis of glycoprotein-based drugs and drug candidates; on the development of industrial processes that use high pressure to minimize the production of waste materials and to reduce/eliminate the need for hazardous chemicals (“green chemistry”); and on the development of an automated, high pressure generator capable of real-time, unattended pressure control up to approximately 58,000 psi.

American Society for Microbiology (ASM) Annual Meeting

The presenting scientist was Dr. Mark Lawrence of Mississippi State University

Data were presented on the use of PCT to help determine the composition of microorganisms in the core of oil wells. Dr. Lawrence indicated that PCT was invaluable in allowing them to isolate bacterial DNA from the community of microorganisms associated with oil deposits. They also indicated that understanding the bacterial community in petroleum deposits was important for the development of improved methods of oil recovery from oil fields.

About Pressure BioSciences, Inc.

Pressure BioSciences, Inc. (PBI) is a NASDAQ Capital Market listed company focused on the development and sale of instrumentation and consumables based on a novel, enabling technology platform called Pressure Cycling Technology (PCT). PCT uses cycles of hydrostatic pressure between ambient and ultra-high levels (up to 35,000 psi and greater) to control bio-molecular interactions. PBI currently holds 24 issued patents covering multiple applications of PCT in the life sciences field, including genomic and proteomic sample preparation, pathogen inactivation, the control of chemical reactions, immunodiagnostics, and protein purification. PBI currently focuses its efforts on the development and sale of PCT-enhanced bio-molecule extraction and enzymatic digestion products designed specifically for the mass spectrometry marketplace, as well as sample preparation products for biomarker discovery, soil and plant biology, forensics, histology, and counter-bioterror applications.