SANTA CLARA, Calif. — Affymetrix, Inc. (Nasdaq: AFFX) today reported that based on preliminary financial data, the Company expects total revenue of approximately $78 million for the first quarter of 2013, including revenue of approximately $19 million from eBioscience. The Company expects to report cash-on-hand of at least $38 million as of March 31, 2013.

“Our revenues for the first quarter were below expectations, primarily due to continued headwinds in our gene expression business across all regions, in particular Japan, where we came in significantly short of plan,” said Frank Witney, president and CEO. “Our genotyping and cytogenetics product lines generated solid growth for the quarter as compared to 2012 and eBioscience also had modest growth from the first quarter of last year. As reported earlier, we ended the quarter with a major win, securing the largest biobank genotyping study to date.”

“Cash-on-hand at the end of March was approximately $38 million, after redeeming the remaining $3.9 million of our 3.5% convertible notes and prepaying $3.2 million of our senior-secured debt,” said Tim Barabe, EVP and chief financial officer. “Our senior secured debt is now at $70 million and debt repayment continues to be one of our priorities in 2013.”

The Company will provide a more detailed business update and complete financial information when it reports its first quarter results after the close of the market on Tuesday, April 30, 2013. The Company is currently observing a pre-earnings quiet period and will not make further comments about its first quarter results in the interim.

Affymetrix’s management team will host a conference call on April 30, 2013 at 2:00 p.m. PT. A live webcast can be accessed by visiting the Investor Relations section of the Company’s website at https://www.affymetrix.com. In addition, investors and other interested parties can listen by dialing domestic: (877) 407-8291, international: (201) 689-8345.

A replay of this call will be available from 5:00 p.m. PT on April 30, 2013 until 8:00 p.m. PT on May 7, 2013 at the following numbers: domestic: (877) 660-6853, international: (201) 612-7415. The conference call passcode to access the replay is 411930. An archived webcast of the conference call will be available under the Investor Relations section of the Company’s website.

About Affymetrix

Affymetrix’s technologies are used by the world’s top pharmaceutical, diagnostic, and biotechnology companies, as well as leading academic, government, and non-profit research institutes. More than 2,300 microarray systems have been shipped around the world and more than 48,000 peer-reviewed papers have been published citing our technologies. Affymetrix is headquartered in Santa Clara, California, and has manufacturing facilities in Cleveland, Ohio, San Diego, Vienna and Singapore. The Company has about 1,100 employees worldwide and maintains sales and distribution operations across Europe, Asia, and Latin America. For more information about Affymetrix, please visit www.affymetrix.com.

Affymetrix has not filed the Form 10-Q for the first quarter of fiscal 2013. As a result, all financial results described in this press release should be considered preliminary, and are subject to change to reflect any necessary corrections or adjustments, or changes in accounting estimates, that are identified prior to the time the company is in a position to complete these filings.