NewswireToday – /newswire/ – San Jose, CA, United States, 05/01/2009 – AnaSpec has announced the release of the newest addition to its Anti-MOG ELISA assay kit series – the SensoLyte Anti-Human MOG (1-125) IgG Quantitation ELISA Kit.

This kit, along with previously featured SensoLyte Anti-Mouse MOG (1-125) and SensoLyte Anti-Rat MOG (1-125) IgG ELISA assay kits are useful for determining the amount of anti-human MOG (1-125), anti-mouse MOG (1-125) and anti-rat MOG (1-125) antibodies, respectively. These kits, as well as the recombinant MOG (1-125) proteins are examples of innovative products from AnaSpec.

MOG (1-125) is found in the extracellular domain of Myelin Oligodendrocyte Glycoprotein (MOG). MOG is a member of the immunoglobulin superfamily and is expressed exclusively in the central nervous system (CNS). Although MOG protein constitutes only 0.01-0.05% of the CNS myelin proteins, it is demonstrated that MOG protein is a crucial autoantigen for multiple sclerosis in humans and experimental autoimmune encephalomyelitis (EAE) in rodents and monkeys.1-6

References:

1. Linares, D. et.al. Protein Exp. Purif. 34, 249 (2004).

2. Bettadapura, J. et.al. J. Neurochem. 70, 1593 (1998).

3. Oliver, AR. et al J. Immunol. 171, 462 (2003).

4. Von Budingen, H. et.al. J. Clin. Immunol. 21, 155 (2001).

5. Lyons, J. et.al. Eur. J. Immunol. 29, 3432 (1999).

6. Von Budingen, H. et.al. Eur. J. Immunol. 34, 2072 (2004).

About AnaSpec

AnaSpec (anaspec.com) is a leading provider of integrated proteomics solutions to the world’s largest biotech, pharmaceutical, and academic research institutions. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents, and combinatorial chemistry.