CE Systems, Particle Analyzers, Centrifuge Key Offerings

ORANGE COUNTY, Calif. – Beckman Coulter, Inc. will exhibit a portfolio of laboratory solutions that serve biotherapeutic formulation scientists at this year’s Pharmaceutical Sciences World Congress, convening Nov. 14-18 at the Morial Convention Center in New Orleans. Instruments in the suite can be used for characterizing protein charge, analyzing individual protein molecules, studying formation of dimers and trimers and for quantifying large aggregates in applications from basic biochemical discovery through large-scale production.

A capillary electrophoresis system, micro-ultracentrifuge and particle size analyzers will be available for viewing in Booth 346, along with systems experts who can answer questions and offer advice regarding specific applications. Featured technologies will include the PA 800 plus Pharmaceutical Analysis System*, a next-generation CE platform that integrates quantitative, qualitative and automated solutions for analysis of protein purity, charge isoform distribution and glycan heterogeneity.

The Optima MAX-XP Micro-Ultracentrifuge, which is ideal for protein formulation applications, will be on display. This centrifuge can produce sedimentation forces greater than 1,000,000 x g, features an intuitive, customizable user interface and incorporates a number of enhanced biosafety attributes.

Quantifying aggregates between 1 and 10 microns is a hot topic in protein formulation, and Beckman Coulter’s aggregate counting solution, the Multisizer 4, will feature a new sample holder that enables working with volumes as small as 4 mL. The DelsaNano, Beckman Coulter’s dynamic light scattering and zeta potential solution, will be shown, and can be used for sizing proteins in solution and quickly studying their stability. Completing the Particle Characterization offerings, the LS 13 320 laser diffraction system can size therapeutics ranging from 0.017 to 2000 microns in dry powders, aqueous suspensions or solvents.

“Our full range of analytical products provides the formulation scientist with the ability to fully characterize the activity and components of their samples,” said Matthew Rhyner, PhD, technical marketing manager in the Beckman Coulter Particle Characterization Business Center. “We look forward to talking with researchers and development specialists at the conference and helping them optimize their workflow.”

Booth staff will be available to discuss the ProteomeLab XL-I Protein Characterization System*, which, while not being exhibited, will be of interest to protein chemists. This analytical centrifuge provides large quantities of information about protein formulations by sequentially collecting data from an on-board scanning UV/Vis detection system and Rayleigh Interference Optics.

About Beckman Coulter

Beckman Coulter, Inc., based in Orange County, California, develops, manufactures and markets products that simplify, automate and innovate complex biomedical tests. This year marks the company’s 75th anniversary of advancing healthcare. More than 200,000 Beckman Coulter systems operate in laboratories around the world, supplying critical information for improving patient health and reducing the cost of care. Recurring revenue, consisting of consumable supplies (including reagent test kits), service and operating-type lease payments,

represents about 80 percent of the company’s 2009 revenue of $3.3 billion. For more information, visit www.beckmancoulter.com or www.beckmancoulter.com/75years.

* For Laboratory Use Only; not for use in diagnostic procedures.

Beckman Coulter and the stylized logo are registered trademarks of Beckman Coulter, Inc.

Optima, DelsaNano, LS, Multisizer and ProteomeLab are trademarks of Beckman Coulter, Inc.