BellBrook Labs Awarded Patent on Transcreener® HTS Assay for Glycosyltransferases

BellBrook Labs announced today that they have been awarded a fourth U.S. patent for their innovative line of Transcreener® HTS Assay kits. This new patent, U.S. 7,847,066, describes the invention of a universal assay for UDP-glycosyltransferases based on direct detection of UDP in a high-throughput format.

Madison, WI – It was announced today that the U.S. Patent and Trademark Office has awarded BellBrook Labs’ Transcreener® technology its fourth patent (U.S. 7,847,066) for their innovative Glycosyltransferase assay.

There are over 200 glycosyltransferases encoded in the human genome that use either UDP-, GDP- or CMP-activated sugars as the donor substrates. UDP-glycosyltransferases are the most abundant and they play a key role in metabolism of drugs. In the Transcreener® UDP Assay, the detection of UDP produced in the enzyme reaction allows for a universal system to measure UDP-glycosyltransferase activity with any acceptor substrate. Because it allows homogenous, mix-and-read detection, the Transcreener® HTS Assay platform offers significant advantages over other assay methods that require separation steps.

In combination with existing Transcreener® assays for GDP and CMP, the newly patented technology will accelerate the discovery of improved drugs targeting glycosylation events in diseases, such as cancer, type II diabetes and neurodegeneration.

About BellBrook Labs. BellBrook Labs, LLC develops detection reagents and microfluidic devices that accelerate the discovery of more effective therapies for cancer and other debilitating diseases. Transcreener® is a patented high throughput screening assay platform that was introduced in 2005 and is used to identify inhibitors for kinases and other types of protein drug targets. The iuvo™ Microconduit Array technology and assay screening service is a line of unique microscale devices for miniaturization and automation of advanced cell models that are more representative of human physiology. Visit BellBrook’s website for more information: https://www.bellbrooklabs.com.

BellBrook Labs Awarded Patent on Transcreener® HTS Assay for Glycosyltransferases

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