Advanced Tools for Quantitative 3D Molecular Imaging, Bioluminescence and Fluorescence Spectral Unmixing of Small Animals

HOPKINTON, Mass. — Caliper Life Sciences, Inc. (Nasdaq: CALP – News), a leading provider of tools and services for drug discovery and life sciences research, today introduced Living Image 4.0 software for IVIS® in vivo imaging systems. Living Image software drives the more than 800 Caliper IVIS systems currently installed in laboratories worldwide. Living Image 4.0 features advanced spectral unmixing tools to enhance fluorescent sensitivity and automated 3D image acquisition and analysis providing an anatomical view of disease activity and drug efficacy.

Preclinical imaging for translational research is now routinely used in large scale studies for drug discovery and vaccine development. With Living Image 4.0, scientists can easily visualize and track diseases quantitatively, in small living animals through the sensitive detection of fluorescent and bioluminescent reporters and functional markers. 3D images generated with Living Image 4.0 can also be co-registered with CT or MRI results to provide enhanced anatomical context for optical molecular signals.

The software’s new design creates an intuitive, seamless workflow for researchers of all skill levels. New features include: wizard based guidance for advanced imaging protocols, improved surface tomography, advanced spectral unmixing tools, new color templates and 3D visualization tools. All IVIS systems are calibrated to NIST standards to ensure that quantitative results are validated throughout an experiment and from location to location.

“Caliper’s IVIS systems are widely recognized as the leading small animal molecular imaging instrument for drug discovery and development,” said Kevin Hrusovsky, president and chief executive officer, Caliper Life Sciences. “Living Image 4.0 will further enhance IVIS’s value to scientists by improving its ease-of-use, quantitation and reproducibility.”

Living Image 4.0 began shipping with all new IVIS in vivo imaging systems on November 30, 2009. Upgrades to Living Image 4.0 for existing IVIS systems will be available for purchase January 1, 2010.

For additional information on Caliper’s portfolio of optical imaging systems, please visit http://www.caliperls.com/products/optical-imaging/.

About Caliper Life Sciences

Caliper Life Sciences is a premier provider of cutting-edge technologies enabling researchers in the life sciences industry to create life-saving and enhancing medicines and diagnostic tests more quickly and efficiently. Caliper is aggressively innovating new technology to bridge the gap between in vitro assays and in vivo results, enabling the translation of those results into cures for human disease. Caliper’s portfolio of offerings includes state-of-the-art microfluidics, lab automation & liquid handling, optical imaging technologies, and discovery & development outsourcing solutions. For more information please visit www.caliperLS.com.

Caliper, Living Image and IVIS are registered trademarks of Caliper Life Sciences, Inc.

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