Cytiva transforms protein purification with its new affinity technology that works with any recombinant protein

  • New tag technology is self-cleaving and traceless, helping drug developers and manufacturers obtain pure proteins without remaining tag residues.
  • New affinity chromatography resin and tag combination is applicable from early research through to bioprocessing.

Protein Select HiTrap product

Cytiva, a global leader in life sciences, introduces the innovative Cytiva Protein Select technology, designed to streamline and accelerate recombinant protein purification. The self-cleaving traceless tag and complementary affinity chromatography resin standardizes purification for any protein, rendering it unnecessary to use specific affinity binding partners for each protein.

Amanda Halford, President Bioprocess at Cytiva, shares her excitement about this technology: “We’ve worked closely with customers to understand their challenges. We’re offering an innovative solution that simplifies a complex issue, benefiting the entire protein research, drug development, and manufacturing pipeline.”

Protein purification is integral to basic research, drug discovery, process development, and bioprocessing. However, the diverse family of recombinant proteins – of which there are 1800 in the global pipeline1 this year alone – often lacks affinity binding partners to facilitate purification. A common strategy to facilitate the purification has been to add a tag to the protein; however, it cannot be removed cleanly for biotherapeutic applications. Thanks to Cytiva Protein Select technology, scientists can confidently purify proteins using a simple protocol and receive highly pure, native proteins free of tag amino acids.

Protein Select resin and Protein-Select HiTrap family image

Process developers using this technology will experience easier, faster, and more efficient process development. Furthermore, the developed processes will become quicker and more cost-effective, requiring fewer chromatography steps.

For protein researchers, removing tags is crucial in applications like structural studies. With Cytiva Protein Select resin and tag, a single step replaces the traditional three-step tagged protein purification, making the protocol simpler and faster. Now, researchers can unveil the true essence of their protein of interest, ensuring functional and structural studies are reliable.

Customers will be able to purchase Cytiva Protein Select resin from early 2024.

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About Cytiva

At Cytiva, our mission is to advance and accelerate the development of therapeutics. With nearly 16 000 associates in more than 40 countries, we’re driven to use our expertise and talent to achieve better flexibility, capacity, and efficiency for our customers. Our broad and deep portfolio of tools and technologies, global scale, and best-in-class service provides critical support from discovery to delivery, for customers spanning researchers, emerging biotech, large-scale biopharma and contract manufacturers.

1 Source GlobalData
* Cytiva Protein Select™ is a trademark of Global Life Sciences Solutions USA LLC or an affiliate doing business as Cytiva.

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