A new “Tools for ADME/Tox” resource guide is now available

LGC Standards has launched a new absorption, distribution, metabolism, and excretion (ADME) toxicology guide comprising a unique collection of labelled and unlabelled reagents and standards, as well as important biological model systems.

The Tools for ADME/Tox guide provides reference to Food and Drug Administration (FDA) guidelines and has specifically been developed for preclinical drug discovery and development scientists working across the spectrum of ADME and toxicology preclinical drug discovery and research.

The guide’s quick reference tables provide details of key metabolising enzymes with relevant substrates, metabolites, inhibitors and inducers. These tables then link to an alphabetical product listing which enable researchers to easily locate the specific reference standards and reagents required for their assays. The listing includes FDA Drug Development and Drug interaction guidance listing substrates, inhibitors and inducers as either preferred or acceptable. A significant number of metabolite standards are also available both labelled and unlabelled, with each product format’s availability clearly indicated.

The guide comprises a collection of model systems commonly used in preclinical drug discovery research. The range includes fresh hepatocytes from a series of species, available the day after isolation and key immortalised cell lines such as Caco-2 (HTB-37™) and primary cells from ATCC®.

LGC Standards has developed strong partnerships with many of the world’s leading standards and reference material producers. These partnerships, combined with our own recognised and accredited production capabilities, positions LGC Standards as a key supplier to both research and quality control laboratories across a diverse range of industries. LGC Standards in partnership with ATCC has supplied biological cultures and bio products to the European life science research community for almost 10 years.

To obtain your copy of the new Tools for ADME/Tox resource guide, please contact LGC Standards by email at pharma@lgcstandards.com or telephone: +44 (0)20 8943 8480.

About LGC Standards

LGC Standards (www.lgcstandards.com) provides products and services to improve measurement and quality control within the laboratory, and is part of LGC, whose Research and Technology Division acts as the UK National Measurement Institute for Chemical and Biochemical Measurements. LGC Standards supplies over 20,000 reference materials, pharmaceutical impurity reference standards, proficiency testing and training in analytical quality. LGC Standards is headquartered in Teddington, Middlesex, UK. Its global centre for excellence in proficiency testing is located in Bury (Greater Manchester). LGC Standards has offices in France, Germany, Italy, Poland, Spain, Sweden, China, Russia and the UK, a joint venture presence in India, and representatives in Bulgaria, Czech Republic, Finland, Hungary, Ireland, Romania, Turkey and the US.

About LGC

LGC (www.lgc.co.uk) is an international science-based company and market leader in analytical, forensic and diagnostic services and reference standards. A progressive and innovative enterprise, LGC operates in socially responsible fields underpinning the safety, health and security of the public and the regulation of industry, for UK government departments and blue chip clients.

LGC operates internationally through four divisions – LGC Forensics, Life & Food Sciences, LGC Standards and Research & Technology, which includes specialist laboratories delivering contracts under the Department for Innovation, Universities and Skills (DIUS) and supporting LGC’s designated role as the UK’s National Measurement Institute for chemical and bioanalysis.

Our methodology is extensively accredited to the international standard ISO 17025. With headquarters in Teddington, South West London, the LGC Group employs over 1400 staff in 28 laboratories and centres across Europe and at sites in India, China and the US. Privatised in 1996 and now majority-owned by funds managed by LGV Capital, LGC was founded almost 170 years ago as the Laboratory of the Government Chemist – a statutory function maintained by LGC today.