Technology enhancement offers fast CRISPR DNA editing with fewer off-target effects

Piscataway, New Jersey

?GenScript, the number one global provider of gene synthesis services, announced today the launch of its most versatile CRISPR service – synthetic CRISPR RNAs (crRNA). This new addition complements the company’s already extensive CRISPR service and product portfolio.

“Until now, CRISPR constructs have been DNA-based, carrying a risk of insertional mutagenesis, off-target effects, and toxic delivery into stem cells and primary cells,” said GenScript’s CRISPR Services Product Manager, Laura Geuss, Ph.D. “By working immediately after delivery into the cell, our synthetic CRISPR ribonucleoproteins result in quick DNA editing and rapid cell clearance with fewer off-target risks. GenScript’s CRISPR RNAs will expand gene-editing to even more research applications.”

CRISPR RNA, when combined with tracrRNA and Cas9 protein, forms a ribonucleoprotein (RNP) complex that is capable