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Today it is announced that Horizon Discovery and the Human Protein Atlas have entered into partnership. The HPA Cell Atlas program will integrate Horizon’s HPA1 cell line and has selected Horizon’s CRISPR-edited knockout cell models to further expand the knowledge available in the Cell Atlas program.

Horizon Discovery Group plc, a global leader in the application of gene editing and gene modulation for cell line engineering, today announced that it has entered into a partnership with the Human Protein Atlas (HPA). HPA has selected Horizon’s CRISPR-edited knockout cell models to further expand the knowledge available in its Cell Atlas program, to advance the understanding of the genetic drivers of disease. Knockout cell models offer the possibility for an enhanced validation of antibodies based on genetic strategies, because the complete absence of the targeting protein correlates with a complete loss of signal for specific antibodies. Adding more validation data for the HPA’s antibodies will increase the reliability of the Cell Atlas and thereby help users find the most-trustworthy tools for their research.

The growing information database of HPA – proteinatlas.org – is available as open access to scientists in academia and industry in order to explore the human proteome. The Horizon cell models will be integrated specifically within the HPA Cell Atlas program, which details the subcellular localization of proteins in single human cells, providing high-resolution insights into molecular mechanisms. Initially, HPA researchers will utilize 500 of Horizon’s CRISPR-edited knockout cell models as part of large-scale protein expression and imaging studies.

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