Immobilized Chiral Columns Pave the Way to Novel Separations

WEST CHESTER, Pa. — High-speed analysis and reproducible results are paramount to efficient pharmaceutical research and development. CHIRALPAK® IA, IB and IC immobilized polysaccharide columns from Chiral Technologies allow chemists to choose from a large assortment of organic solvents. Use of CHIRALPAK immobilized columns helps to develop new separations and attain high levels of enantioselective recognition of chiral molecules.

The choice of mobile phase content in both enantioselective high-performance liquid chromatography (HPLC) and supercritical fluid chromatography (SFC) has expanded dramatically to a greater variety of organic solvents due to the stability of the immobilized polysaccharide phases. By using practically any organic solvent in conjunction with three immobilized chiral stationary phases (CSPs) — CHIRALPAK IA, IB or IC — chemists can maximize success rates in compound screening for identifying an effective separation of chiral molecules by enantioselective HPLC and SFC.

Additionally, immobilized column selectivities are complementary to those of coated polysaccharide-based CSPs, leading to a high degree of success in screening for a successful separation method using the available coated phases in a combination with CHIRALPAK IA, IB and IC.

The immobilized columns have been successfully employed in pharmaceutical research and development applications. The advent of CHIRALPAK IA, IB and IC offers enhanced compound solubility, greater column stability and novel column selectivity, all of which improve column lifetime.

For more information about immobilized CSPs from Chiral Technologies, Inc. visit https://www.chiraltech.com/col_csp.asp.

About Chiral Technologies, Inc.

Chiral Technologies Inc. is the market leader in enantioselective chromatography. The company provides innovative solutions for research and development of chiral molecules. Chiral Technologies supplies bulk chiral stationary phases, and analytical and preparative chiral columns for chromatographic resolution of racemic mixtures into single enantiomers. Located in West Chester, Pa., the company operates an outsourcing center for custom separation of chiral intermediates and APIs on milligram to multi-kilogram scales for pre-clinical and clinical evaluation. Chiral Technologies has served the pharmaceutical and other life science industries since its founding in 1990. www.chiraltech.com

Immobilized Chiral Columns Pave the Way to Novel Separations

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