Paper Published in Nature Demonstrates Mutational Burden Caused by Tobacco Smoking uen

CARLSBAD, Calif.–Applied Biosystems, part of Life Technologies Corporation (NASDAQ:LIFE – News), today announced the publication of a paper in the journal Nature that demonstrates the power of next-generation DNA sequencing used to identify DNA mutations in a small cell lung cancer (SCLC) line and identify the mutational burden associated with tobacco smoking. The paper, authored by researchers from the Wellcome Trust Cancer Institute and co-authored by Applied Biosystems, demonstrates the potential for next-generation sequencing to provide unprecedented insights into mutational processes, cellular repair pathways and gene networks associated with cancer development.

“The publication of this paper emphasizes the power that next-generation sequencing, such as Applied Biosystems’ SOLiD™ System, has to improve science’s understanding of disease and its potential to develop better diagnostics and therapeutic treatment,” said Kip Miller, President, Genetic Systems for Life Technologies. “Today’s SOLiD 3 Plus System offers even more capability and is faster, more robust and more economical than the SOLiD 2.0 System that generated the data in the paper.”

These impactful results were generated at the Sanger Institute using an early version of the SOLiD System. Massively parallel sequencing on Applied Biosystems’ SOLiD 2.0 System enabled the researchers to identify all of the mutations in the SCLC line NCI-H209 and compare them to a matched normal cell line. Data identified several mutation signatures that reflect the wide range of carcinogens in tobacco smoke, which is notable because 90 percent of patients with SCLC smoked during their lives.

Today’s SOLiD 3 Plus System is capable of generating over 60Gb of mappable sequence at an accuracy greater than 99.95 percent.

To read the complete paper, please visit http://www.nature.com/nature/journal/vaop/ncurrent/full/nature08629.html.

About Life Technologies

Life Technologies Corporation (NASDAQ:LIFE – News) is a global biotechnology tools company dedicated to improving the human condition. Our systems, consumables and services enable researchers to accelerate scientific exploration, driving to discoveries and developments that make life even better. Life Technologies customers do their work across the biological spectrum, working to advance personalized medicine, regenerative science, molecular diagnostics, agricultural and environmental research, and 21st century forensics. Life Technologies had sales of more than $3 billion in 2008, employs approximately 9,500 people, has a presence in more than 100 countries, and possesses a rapidly growing intellectual property estate of approximately 3,600 patents and exclusive licenses. Life Technologies was created by the combination of Invitrogen Corporation and Applied Biosystems Inc. For more information on how we are making a difference please visit our website: www.lifetechnologies.com. Follow Life Technologies on Twitter @LIFECorporation and on Facebook.

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