Walkersville, MD (USA),– The National Institutes of Health Center for Regenerative Medicine (NIH CRM) has awarded Lonza Walkersville, Inc. a contract to generate induced pluripotent stem cells (iPSCs) under current Good Manufacturing Practices (cGMP). The production of clinical grade iPSCs is considered a critical component to realizing

the therapeutic potential of pluripotent stem cells. The contract also includes manufacturing of clinical grade iPSC-derived cell types.

In 2007, Dr. Shinya Yamanaka and colleagues at Kyoto University became the first to successfully convert adult human cells to an embryonic stem cell-like state. In 2012, Yamanaka was awarded a Nobel Prize for this work. One defining characteristic of these induced pluripotent stem cells is their ability to become any cell type in the body. Therefore,

iPSC technology can be used to develop cell transplantation therapies for the treatment of degenerative diseases such as diabetes, Parkinson’s Disease and a number of cardiovascular diseases. Lonza is a global licensee of the technologies invented by Dr. Yamanaka.

“As the world leading cell therapy contract manufacturer, Lonza is committed to the field of regenerative medicine. Our goal is to help cell therapy developers navigate the complexities of process optimization and cGMP-compliant manufacturing for clinical trials and beyond,” said Lukas Utiger, President, Lonza Walkersville. “Being awarded this contract further validates Lonza’s position as the partner of choice for moving iPSC technology into the clinic.”

The contract awarded to Lonza is deemed an Indefinite Delivery/Indefinite Quantity (IDIQ) award which is a type of United States Government contract that provides an indefinite quantity of services for a fixed amount time. For IDIQs, although nothing is guaranteed, minimum and maximum quantity limits are specified in the basic contract as either number of units (for supplies) or as dollar values (for services). The Lonza contract is a five year agreement with a value of approximately $9.5 million dollars.

Further information on Lonza’s pluripotent stem cell technology development programs and service offerings can be found at www.lonza.com/pluripotent.

About the NIHCenter for Regenerative Medicine

Supported by the NIH Common Fund, the NIH Center for Regenerative Medicine (NIH CRM) is a community resource that works to provide the infrastructure to support and accelerate the clinical translation of stem cell-based technologies, and to develop widely available resources to be used as standards in stem cell research. For a variety of patient populations, the Center facilitates generation of induced pluripotent stem cells (iPSCs), as well as the derivation or isolation of other types of stem cells. The Center makes available a range of adult stem and progenitor cell populations, as well as the protocols and standard operating procedures (SOPs) used for their derivation, culture, and differentiation. The Center provides services and information to both the intramural and extramural NIH communities that facilitate the use of stem cell technologies for therapeutic purposes and for screening efforts. The Center collaborates in the U.S. and internationally — including governments, research institutions and commercial entities — to ensure that efforts are coordinated and standard policies are in place to minimize roadblocks to advancing stem cell technologies. For more information on the NIH CRM, visit www.crm.nih.gov.

About Lonza

Lonza is one of the world’s leading suppliers to the pharmaceutical, healthcare and life science industries. Products and services span its customers’ needs from research to final product manufacture. It is the global leader in the production and support of chemical and biological active pharmaceutical ingredients. Biopharmaceuticals are one of the key growth drivers of the pharmaceutical and biotechnology industries. Lonza has strong capabilities in large and small

molecules, peptides, amino acids and niche bioproducts which play an important role in the development of novel medicines and healthcare products. Lonza is also the world leader in microbial control providing innovative, chemistry-based and related solutions to destroy or to selectively inhibit the growth of harmful microorganisms. Its activities encompass the areas of water treatment, personal care, health and hygiene, industrial preservation, materials protection, and wood treatment. In addition, Lonza is a leader in cell-based research, endotoxin detection and cell therapy manufacturing. Furthermore, the company is a leading provider of value chemical and biotech ingredients to the nutrition and agro markets.

Lonza is headquartered in Basel, Switzerland and is listed on the SIX Swiss Exchange and secondary listed on the Singapore Exchange Securities Trading Limited (“SGX-ST”). Lonza is not subject to the SGX-ST’s continuing listing requirements. Lonza is subject to the listing rules of the SIX Swiss Exchange, which do not have specific requirements equivalent to the listing

rules of the SGX-ST in respect of interested person transactions, acquisition and realizations, and delisting. In 2011, the company had sales of CHF 2.692 billion. Further information can be

found at www.lonza.com.