Symyx Unveils New Enterprise Electronic Laboratory Notebook Streamlining Operations, Enhancing Collaboration, Lowering Costs and Accelerating Productivity for R&D SANTA CLARA, CA–Apr 28, 2008 — Symyx Technologies, Inc. (NasdaqGS:SMMX – News) today announced availability of Symyx Notebook — a new, enterprise electronic laboratory notebook (ELN) that is configurable to meet the needs of biologists and analytical chemists out-of-the-box. Symyx Notebook simplifies laboratory operations and lowers costs by enabling R&D organizations to replace multiple discipline-specific ELNs with a single, multi-discipline application that is deployable across the enterprise. Symyx Notebook gives project teams the freedom to experiment with confidence in a collaborative research environment. “Symyx Notebook is a key component of Symyx’s vision and product roadmap. Built on an enterprise-scale informatics platform, Symyx Notebook consolidates experimental data from multiple domain areas into fully versioned, shareable and searchable documents controlled by customizable document workflows with secure document versioning, electronic signatures and audit trails,” said Timothy Campbell, President, Symyx Software. “Symyx Notebook delivers on our vision of an automated, paperless lab where scientists focus on science, not on software development, giving them the freedom to experiment with confidence in a flexible research environment.” Symyx Notebook is the result of close collaboration with several large pharmaceutical and chemical companies and Symyx’s broad experience with electronic notebooks in large, multi-site deployments. By enabling research groups to configure, deploy and fine-tune discipline-specific templates out-of-the-box, Symyx Notebook accelerates laboratory workflows and improves R&D productivity. Symyx Notebook introduces the following benefits for scientists today: — Full Software Developer Kit permitting rapid creation of custom functionality and extensions including incorporation of third-party software — Superior searching and browsing enabled via full-text searching of data-entry forms, experiments, embedded files and annotations; Boolean searching of data-entry forms quickly narrows result sets — Improved consistency and streamlined editing of experiments with ability to create different experiment templates spanning multiple scientific disciplines; ability to drag-and-drop files and annotate experimental data and images — Single application to deploy and maintain significantly minimizes IT setup while facilitating systems management and integration; new functionality and third-party add-ins automatically downloaded from the server when needed — Citrix® compatibility eliminating need to install application on researchers’ desktops, facilitating remote access and enabling operation with Microsoft® Windows®, Mac OS® and Linux® operating systems Symyx Notebook uses the Symyx Vault document management platform. Symyx Vault supports document browsing and searching, 21CFR11-compliant electronic signatures and audit trails, enterprise-level security and configurable, highly flexible document workflows with secure versioning for single- and multi-site deployments of all sizes. Symyx Notebook improves R&D productivity and decision confidence by enabling scientists working in diverse disciplines to access, analyze and share experimental data within a single, enterprise notebook application — enhancing data consistency, integrating domain area activities and accelerating experimental workflows. Symyx Notebook is available now. For more information, visit www.symyx.com or contact [email protected]. About Symyx Symyx Technologies, Inc. is the scientific R&D integration partner to companies in the life sciences, chemicals, energy, electronics and consumer products industries. With scientific R&D under tremendous economic and technical pressure, we help companies reduce R&D risk and enhance R&D productivity to help them bring more and better products to market quickly and cost-effectively. Our integrated technology platform combines Symyx Software — electronic laboratory notebooks, content, laboratory logistics and analysis; Symyx Tools — software-driven integrated workflows; and Research — collaborative research and directed services to support the entire R&D process. Information about Symyx, including reports and other information filed by Symyx with the Securities and Exchange Commission, is available at www.symyx.com. Symyx is a registered trademark of Symyx Technologies, Inc. All rights reserved. Citrix is a registered trademark of Citrix Systems, Inc. in the United States and other countries. Linux is a registered trademark of Linus Torvalds. Mac OS is a registered trademark of Apple Computer, Inc. Microsoft and Windows are registered trademarks of the Microsoft Corporation in the United States and other countries. All other trademarks mentioned in this document are the property of their respective owners.