CARLSBAD, Calif. — Biopharmaceutical companies developing protein-based therapeutics now have access t o a new t ransient CHO expression syst em designed t o great ly enhance early phase drug screening.

The Gibco ExpiCHO Expression System is a fully redesigned transient expression system that enables biologics developers to produce proteins in CHO cells from discovery to manufacture and provides a more efficient and seamless drug development workflow. The ExpiCHO system can achieve protein yields of up to 3 grams per liter.

“Due to its unprecedented protein yields, the ExpiCHO system makes it possible to quickly and cost-effectively generate potential drug candidates in CHO cells, rather than in human 293 cells,” said Rik Basi, senior marketing manager for cell biology at Thermo Fisher Scientific.

“The ExpiCHO system helps speed up our developmental timelines by eliminating the need to have different hosts for transient versus stable expression. This eliminates a key quality risk when we transition from research into development,” said Neeraj Kohli, associat e direct or at Merrimack Pharmaceut icals.

The ExpiCHO Expression System brings together a high-expressing CHO cell line, a chemically defined animal origin–free culture medium, an optimized culture feed, and a high-efficiency transfection reagent. Together, these components provide titers that exceed existing CHO expression systems by 160-fold.

“The ExpiCHO Expression System provides simple and flexible protocols designed to achieve the perfect balance of protein yields, speed and scalability to meet specific needs and applications,” said Jonathan Zmuda, R&D leader at Thermo Fisher. “ExpiCHO also delivers an alternative option for proteins that do not express well in other systems.”

For more information on the Gibco ExpiCHO Expression System, click here.

Gibco ExpiCHO Expression System is for Research Use Only. Not for use in diagnostic procedures. About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. is the world leader in serving science, with revenues of $17 billion and approximately 50,000 employees in 50 countries. Our mission is to enable our customers to make the world healthier, cleaner and safer. We help our customers accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics and increase laboratory productivity. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services – we offer an unmatched combination of innovative technologies, purchasing convenience and comprehensive support. For more information, please visit www.thermofisher.com.