SOUTH EASTON, Mass., — Pressure BioSciences, Inc. (OTCQB: PBIO) (“PBI” or the “Company”) today announced that two research groups have reported on the ability of the Company’s Pressure Cycling Technology (“PCT”) Platform to improve the detection of DNA in challenging forensic samples. The studies were presented by scientists from the Institute of Applied Genetics, Department of Forensic and Investigative Genetics, University of North Texas Health Science Center (“UNTHSC”) in Fort Worth Texas, and from the Harris County Institute of Forensic Sciences in Houston Texas. The study results were presented at the 23rd annual International Symposium on Human Identification (“ISHI”), being held from October 15-18, 2012, in Nashville, TN.

DNA testing on forensic samples is performed to help in the identification of individuals by their unique DNA profile. Samples that contain suboptimal quantity and/or quality of DNA are commonly encountered in forensic DNA analysis. One such problem is the presence of DNA contaminants or inhibitors in the sample, which can effectively reduce the detection of DNA, potentially causing a poor or even invalid result. Lessening the effects of these contaminants/inhibitors should improve the quality of the forensic (or for that matter, any) DNA test.

Dr. Bruce Budowle, Executive Director of the Institute of Applied Genetics at UNTHSC, said: “Our results indicate that DNA testing can be enhanced by treating forensic samples that contain inhibitory compounds with PCT. We consider our study as a proof of concept that PCT treatment might be a viable method to overcome certain inhibitory effects that can adversely affect DNA testing. Importantly, it appears that PCT can reduce the effects of inhibitors known to be present in some bone samples, resulting in a marked improvement in DNA testing of these often difficult samples.”

Dr. Nate Lawrence, Vice President of Sales and Marketing of PBI, commented: “We believe the results of these studies show that incorporating PCT into the standard workflow of the forensic DNA testing laboratory could significantly enhance both the productivity and quality of DNA testing. We further believe that this enhancement in testing will result in solving difficult and/or unsolved cases.”

Dr. Lawrence continued: “To that end, we have spent a number of hours at the ISHI meeting talking with forensic scientists about these results, and what they need to incorporate PCT into their daily DNA testing workflows. With this knowledge in hand, we are planning to accelerate the development of our forensic-based instruments and consumables, with an expectation that the release of these products will positively affect revenue in 2013.”

About Pressure BioSciences, Inc.

Pressure BioSciences, Inc. (“PBI”) (OTCQB: PBIO) is focused on the development, marketing, and sale of proprietary laboratory instrumentation and associated consumables based on Pressure Cycling Technology (“PCT”). PCT is a patented, enabling technology platform with multiple applications in the estimated $6 billion life sciences sample preparation market. PCT uses cycles of hydrostatic pressure between ambient and ultra-high levels to control bio-molecular interactions. PBI currently focuses its efforts on the development and sale of PCT-enhanced sample preparation systems (instruments and consumables) for mass spectrometry, biomarker discovery, bio-therapeutics characterization, vaccine development, soil and plant biology, forensics, histology, and counter-bioterror applications.