South Easton, MA,– Pressure BioSciences, Inc. (OTCQB: PBIO) (“PBI” and the “Company”) today announced that its common stock will begin trading on the OTCQB tier of the OTC Marketplace (“OTCQB”) effective today, Thursday, April 5, 2012. The OTCQB is a market tier for OTCtraded companies that are registered and current in their reporting with the Securities and Exchange

Commission, and is the home to approximately 3,500 small and emerging companies. The Company’s shares of common stock will continue to trade under the symbol PBIO.

The Company’s common stock will cease trading on the NASDAQ Stock Market effective with the open of business on Thursday, April 5, 2012. As previously reported, the NASDAQ Hearings Panel required the Company to evidence compliance with the applicable $2.5 million stockholders’ equity requirement and the minimum $1.00 per share bid price requirement to maintain its NASDAQ listing. As the Company was unable to do so, the NASDAQ Hearings Panel determined to delist the Company’s

common stock from The NASDAQ Stock Market.

About Pressure BioSciences, Inc.

Pressure BioSciences, Inc. (“PBI”) (OTCQB: PBIO) is focused on the development, marketing, and sale of proprietary laboratory instrumentation and associated consumables based on Pressure Cycling Technology (“PCT”). PCT is a patented, enabling technology platform with multiple applications in the estimated $6 billion life sciences sample preparation market. PCT uses cycles of hydrostatic pressure between ambient and ultra-high levels to control bio-molecular interactions. PBI currently focuses its efforts on the development and sale of PCT-enhanced sample preparation systems (instruments and consumables) for mass spectrometry, biomarker discovery, bio-therapeutics characterization, vaccine

development, soil and plant biology, forensics, histology, and counter-bioterror applications.