South Easton, MA – Pressure BioSciences, Inc. (NASDAQ: PBIO) (“PBI” or the “Company”) today announced that it has received gross proceeds of $825,720 from the sale of 55,048 units to 10 accredited investors, including the Company’s CEO and President, in the first tranche of the Company’s $6.0 million Series C private placement.

Each unit was priced at $15.00 (a common share equivalent of $1.50) and consists of (i) one share of non-voting Series C Convertible Preferred Stock, and (ii) one warrant to purchase 10 shares of Common Stock at an exercise price of $2.38 per share, expiring in April 2014. Each share of non-voting Series C Convertible Preferred Stock is convertible into ten shares of the Company’s Common Stock. The closing bid of PBI Common Stock as reported on the NASDAQ Capital Market at the close of business on Thursday, April 7, 2011, the day before the first tranche closing, was $1.12 per common share.

The units were issued in a private placement without registration under the Securities Act of 1933, as amended (the “Securities Act”), in reliance upon the exemption from registration set forth in Rule 506 of Regulation D promulgated under the Securities Act. In connection with the private placement, the Company is paying a cash finder’s fee plus warrants to purchase shares of the Company’s Common Stock to an investment banking firm, expiring in April 2016.

This press release is not an offer to sell or a solicitation of offers to buy units, Series C Convertible Preferred Stock, or warrants. The units, shares of Series C Convertible Preferred Stock, and warrants have not been registered under the Securities Act and may not be sold in the United States absent registration under the Securities Act or an applicable exemption from registration requirements.

About Pressure BioSciences, Inc.

Pressure BioSciences, Inc. (PBI) is a publicly traded company focused on the development and sale of instruments and consumables based on a novel, enabling technology called Pressure Cycling Technology (PCT). PCT uses cycles of hydrostatic pressure between ambient and ultra-high levels (up to 35,000 psi and greater) to control bio-molecular interactions. PBI currently holds 14 U.S. and 10 foreign patents covering multiple applications of PCT in the life sciences field, including genomic and proteomic sample preparation, pathogen inactivation, the control of chemical and enzymatic reactions, immunodiagnostics, and protein purification. PBI currently focuses its efforts in the development and sale of PCT-enhanced enzymatic digestion products designed specifically for the mass spectrometry marketplace, as well as sample preparation products for biomarker discovery, soil and plant biology, forensics, histology, and counter-bioterror applications.e

Forward Looking Statements

Statements contained in this press release regarding PBI’s intentions, hopes, beliefs, expectations, or predictions of the future are “forward-looking” statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward looking statements include statements regarding the potential benefits, improvements and results of using the PCT FFPE System; that cycled pressure and heat are essential for robust and consistent extraction; that pressure-enhanced extraction of FFPE might prove to be a paradigm shifting technology; that the PCT System can efficiently and consistently extract more proteins from FFPE samples; and that the PCT FFPE Extraction System can be market-ready and generate revenue in 2011. These statements are based upon the Company’s current expectations, forecasts, and assumptions that are subject to risks, uncertainties, and other factors that could cause actual outcomes and results to differ materially from those indicated by these forward-looking statements. These risks, uncertainties, and other factors include, but are not limited to: possible difficulties or delays in the implementation of the Company’s strategies that may adversely affect the Company’s continued commercialization of PCT and its PCT-dependent products, including its pressure-based FFPE extraction system; changes in customer’s needs and technological innovations; other scientists may not achieve the same results with PCT reported by scientists in the four recent studies; and the Company’s sales force may not be successful in selling the Company’s PCT product line because scientists may not perceive the advantages of PCT over other sample preparation methods, including in the various areas discussed in the four recent studies. Further, the Company expects that it will need additional capital to fund its continuing operations beyond the first quarter of 2011. Additional risks and uncertainties that could cause actual results to differ materially from those indicated by these forward-looking statements are discussed under the heading “Risk Factors” in PBI’s Annual Report on Form 10-K for the year ended December 31, 2009, and other reports filed by PBI from time to time with the SEC. PBI undertakes no obligation to update any of the information included in this release, except as otherwise required by law.

www.pressurebiosciences.com