South Easton, MA – Pressure BioSciences, Inc. (NASDAQ: PBIO) (“PBI” and the “Company”) today announced that it has unveiled four key instruments in its 2011-2013 product pipeline at the annual meeting of the Association for Mass Spectrometry Applications to the Clinical Lab (MSACL).

Attended by physicians, scientists, and other healthcare professionals, MSACL is an active and influential supporter of the development of new mass spectrometry applications for clinical medicine, including tests for the diagnosis, treatment, and prognosis of clinical disorders. Every major mass spectrometry manufacturer in the U.S. is expected to attend this year’s meeting.

The four key instruments unveiled at MSACL represent an important addition to the Company’s existing pressure cycling technology (PCT) platform. The Company believes that these new products will make a significant impact in the way that research scientists prepare their samples for analysis, particularly scientists working in the estimated $2 billion mass spectrometry market (based upon the findings of the Emmes Group, April 2008). To that end, the Company believes that proof-of-concept has been demonstrated. Data has also been generated and patents have been filed on these very exciting new products, which include:

1.Barocycler HUB440. A manual or computer controlled, compact, portable, and versatile high pressure generator for multiple bioscience applications. Estimated release: Q3 2011.

2.Barocycler FFPE Protein Extraction Service. A service offering the enhanced extraction of proteins from formalin-fixed, paraffin-embedded (FFPE) samples using a modified Barocycler instrument that combines the advantages of pressure cycling, high temperature, and certain reagents. Estimated release: 2012.

3.XstreamPCT™ HPLC Digestion Module. For automated, in-line, on-demand PCT-enhanced protein digestion; the first module in PBI’s PCT-based HPLC platform. Estimated release: 2013.

4.4. Barocycler HT Multiwell (48-384). For high throughput, PCT-enhanced biomolecule extraction/accelerated enzymatic digestion; process 48 – 384 samples. Estimated release: 2013.

In addition, ten presentations related to the Company’s current PCT-based Barocycler product line are scheduled to be presented at the meeting. These presentations are expected to highlight the advantages of PBI’s current products when used in research related to mitochondria (Dr. V. Gross, PBI), cancer (Dr. P. Pevsner, U of MS, and Dr. L. Schneider, Target Discovery), and Klotho (Dr. T. Rezai, Thermo Fisher), a potential biomarker for a number of significant human disorders, including chronic renal disease, osteoporosis, and Alzheimer’s disease.

Mr. Richard T. Schumacher, President and CEO of PBI, said: “We plan on becoming a major supplier of sample preparation instruments and consumables to the large and growing mass spectrometry market. We believe that the four new instruments just unveiled will offer key advantages to current products in this area. Consequently, we will focus significant resources to help ensure the remaining development and subsequent release of these products will proceed as efficiently and rapidly as possible.”

Mr. Schumacher concluded: “We also plan to grow our in-house sales and marketing capabilities and staff, and to find strategic partners to help us rapidly take advantage of this opportunity. This was a compelling reason to unveil the key instruments in our 2011-2013 product pipeline this week at MSACL – to enable us to openly disclose and discuss these instruments with major vendors in the mass spectrometry field, as they are unaware of the significant progress that we have made in this area.”

About Pressure BioSciences, Inc.

Pressure BioSciences, Inc. (PBI) is a publicly traded company focused on the development and sale of instruments and consumables based on a novel, enabling technology called Pressure Cycling Technology (PCT). PCT uses cycles of hydrostatic pressure between ambient and ultra-high levels (up to 35,000 psi and greater) to control bio-molecular interactions. PBI currently holds 14 U.S. and 10 foreign patents covering multiple applications of PCT in the life sciences field, including genomic and proteomic sample preparation, pathogen inactivation, the control of chemical and enzymatic reactions, immunodiagnostics, and protein purification. PBI currently focuses its efforts in the development and sale of PCT-enhanced enzymatic digestion products designed specifically for the mass spectrometry marketplace, as well as sample preparation products for biomarker discovery, soil and plant biology, forensics, histology, and counter-bioterror applications.e

Forward Looking Statements

Statements contained in this press release regarding PBI’s intentions, hopes, beliefs, expectations, or predictions of the future are “forward-looking” statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward looking statements include statements regarding the potential benefits, improvements and results of using the PCT FFPE System; that cycled pressure and heat are essential for robust and consistent extraction; that pressure-enhanced extraction of FFPE might prove to be a paradigm shifting technology; that the PCT System can efficiently and consistently extract more proteins from FFPE samples; and that the PCT FFPE Extraction System can be market-ready and generate revenue in 2011. These statements are based upon the Company’s current expectations, forecasts, and assumptions that are subject to risks, uncertainties, and other factors that could cause actual outcomes and results to differ materially from those indicated by these forward-looking statements. These risks, uncertainties, and other factors include, but are not limited to: possible difficulties or delays in the implementation of the Company’s strategies that may adversely affect the Company’s continued commercialization of PCT and its PCT-dependent products, including its pressure-based FFPE extraction system; changes in customer’s needs and technological innovations; other scientists may not achieve the same results with PCT reported by scientists in the four recent studies; and the Company’s sales force may not be successful in selling the Company’s PCT product line because scientists may not perceive the advantages of PCT over other sample preparation methods, including in the various areas discussed in the four recent studies. Further, the Company expects that it will need additional capital to fund its continuing operations beyond the first quarter of 2011. Additional risks and uncertainties that could cause actual results to differ materially from those indicated by these forward-looking statements are discussed under the heading “Risk Factors” in PBI’s Annual Report on Form 10-K for the year ended December 31, 2009, and other reports filed by PBI from time to time with the SEC. PBI undertakes no obligation to update any of the information included in this release, except as otherwise required by law