SOUTH EASTON, Mass., — Pressure BioSciences, Inc. (OTCQB: PBIO) (“PBI” or the “Company”) today announced that multiple research reports have cited the ability of the Company’s Pressure Cycling Technology (“PCT”) Platform to improve the detection of RNA, DNA, and/or protein in forensic, environmental, and biodefense applications, and in research studies focused on the discovery of biomarkers of disease. These studies were conducted in laboratories worldwide, including:

• Institute of Forensic Sciences (Beijing, China) where scientists concluded that PCT was one of the most effective methods available for extracting DNA from bone in forensic applications. These findings extend earlier studies by other forensic scientists that PCT could lead to better methods of identification of crime victims and bodies of missing persons.

• Lawrence Berkeley National Laboratory (Berkeley, CA) where scientists studying the Deepwater Horizon oil spill in the Gulf of Mexico used PCT to increase cell lysis efficiency. Studies such as this are important in the assessment of the impact of oil spills on the environment.

• Cernomics Solutions (Frederick, MD) where scientists concluded that PCT sterilized and extracted complex, mixed matrix biological samples better than other pre-analytical sample preparation methods available today. Improved methods for safe and effective sample preparation are essential for rapid and robust identification of highly infectious potential bioterror agents, and also to enable better basic research underlying solutions discovery and development.

• Harvard School of Public Health (Boston, MA) where scientists demonstrated that PCT could achieve superior recovery of membrane-associated proteins with more than a 20-fold increase in throughput and with improved reproducibility. The improvement in the recovery of membrane proteins is believed to be critical to the understanding of diseases and disorders such as cancer and Alzheimer’s, and to the discovery of new drug therapies.

The Company believes these findings, together with those from approximately 100 PCT publications already referenced on the Company’s website, strongly support the importance of the PCT Platform in the life sciences field, including its growing role in forensics, environmental analyses, biodefense, and biomarker discovery applications. The Company further believes that this growing role is a primary reason it has experienced increased interest in its PCT Platform during the first half of 2012 and that this increased interest will result in increased revenue for 2012 compared to 2011.

Dr. Brad Powell, President of Cernomics Solutions, said: “The preferential extraction of RNA, DNA, and protein is essential to the development of next generation diagnostics and therapeutics vital to the detection, prevention, treatment, and cure of devastating medical disorders, including infectious diseases, cancer, stroke, and heart disease. Thus, the data generated at Harvard is of particular importance, especially the ability of PCT to recover as much as 3-times the number of certain membrane proteins as other methods. Since membrane proteins are difficult to recover, and since an estimated 80% of all new biological drugs are directed against membrane proteins, any method that can recover significantly more membrane proteins has the potential to be widely used in research laboratories worldwide. Based on my years of experience with PCT, and on the many study results to date, I believe that the PCT Platform has the potential to be transformational in scientific research and development.”

About Cernomics Solutions

Cernomics Solutions is a small business providing contract services to the pharmaceutical, biotechnology, biodefense, and medical and scientific instruments sectors. Consultation services include project management, quality assurance, technical research, and advisory to help clients meet programmatic and business development goals and regulatory requirements. Our staff has extensive experience and expertise in basic and translational research in biotechnology, including vaccine, therapeutics, and diagnostics development for infectious and other diseases.

About Pressure BioSciences, Inc.

Pressure BioSciences, Inc. (“PBI”) (OTCQB: PBIO) is focused on the development, marketing, and sale of proprietary laboratory instrumentation and associated consumables based on Pressure Cycling Technology (“PCT”). PCT is a patented, enabling technology platform with multiple applications in the estimated $6 billion life sciences sample preparation market. PCT uses cycles of hydrostatic pressure between ambient and ultra-high levels to control bio-molecular interactions. PBI currently focuses its efforts on the development and sale of PCT-enhanced sample preparation systems (instruments and consumables) for mass spectrometry, biomarker discovery, bio-therapeutics characterization, vaccine development, soil and plant biology, forensics, histology, and counter-bioterror applications.