- ViewCell™ optimizes downstream processes in the biopharmaceutical industry.
- The flow cell enables safe, continuous process control directly in the production line.
- The innovative process analysis technology (PAT) component acts as a sterile interface between product and optical measurement systems.
MAINZ, GERMANY — Following the market launch of the ViewPort® sensor port for bioreactors, SCHOTT introduces the ViewCell™ flow cell, a new component for biopharmaceutical process analysis. Via a sterile-safe optical window, the flow cell enables in-situ measurements of biological and physical parameters in downstream processing. It can be used during purification and filtration as well as during subsequent formulation. As a result, physical sampling and the need for storage tanks are reduced. Thanks to the special glass-to-metal connection, the seamless and sterile-safe design of ViewCell™ also increases the safety and efficiency of process analysis and thus contributes to an optimized yield.
With the ViewPort® sensor interfaces, SCHOTT already enables in-situ process control when cultivating microorganisms or cells in the upstream process. Pharmaceutical companies can connect optical measuring systems to the SCHOTT® PAT components from the outside and record important process parameters directly and continuously through a highly transmissive optical window. Even the smallest deviations can thus be detected and adjusted immediately.
Now, with the ViewCell™ flow cell, these advantages can be utilized at other, additional points in biopharmaceutical production as well. “From filtration to formulation, the flow cell can be integrated into the product stream of various multi-use or single-use plants in the downstream process,” explains Christian Ott, Head of R&D Biotech at SCHOTT. „There, ViewCell™ enables continuous in-situ measurement of multiple process parameters of the medium flowing through it, which supports pharmaceutical companies in their process intensification.”
Optical sensors or spectrometers are connected to the flow cell for monitoring. Since the measuring instruments do not come into contact with the medium, i.e., they do not penetrate the sterile barrier, they can easily be replaced during ongoing production. That is a major advancement compared to fixed probes.
The new, sterilizable flow cell from SCHOTT is made of materials that comply with best practices in the pharmaceutical industry: viewing windows made of sapphire, glass, and stainless steel. Alternatively, SCHOTT offers pre-sterilized variants of ViewCell™ for single-use applications. All variants are durable, processed without adhesives or other auxiliary materials due to the special glass-to-metal connection, and can be used in a safe and sterile manner. In addition, to support GMP requirements, SCHOTT® PAT components are provided with an individual data matrix code.
ViewPort® and ViewCell™ are registered trademarks of SCHOTT AG.