Sequenom Announces Paul Maier to Become Interim Chief Financial Officer

SAN DIEGO — Sequenom, Inc. (Nasdaq: SQNM – News), today announced that Paul V. Maier has been appointed as the company’s interim chief financial officer effective November 10, 2009, reporting directly to the company’s interim chief executive officer and chairman of the board, Harry F. Hixson, Jr., Ph.D.

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Prior to the effective date of Mr. Maier’s appointment as interim chief financial officer, Mr. Maier will act as a consultant to the company.

“I am delighted that Paul has agreed to join Sequenom as our interim CFO,” said Dr. Hixson. “His wealth of experience, including over 20 years in the pharmaceutical and biotechnology industry makes him an ideal fit for us. Paul will play an important role as we look to strengthen our financial position and strategically position ourselves for product launches and growth.”

Mr. Maier has been an independent financial consultant since February 2007. Mr. Maier served as senior vice president and chief financial officer of Ligand Pharmaceuticals Incorporated from 1992 until January 2007, where he helped build Ligand from a venture stage boutique company to a commercial, integrated biopharmaceutical organization. During his tenure at Ligand, Mr. Maier helped raise over $1 billion in equity and debt financings. Prior to Ligand, Mr. Maier spent six years in various management and finance positions at ICN Pharmaceuticals.

About Sequenom

Sequenom, Inc. (NASDAQ: SQNM – News) is a life sciences company committed to improving healthcare through revolutionary genetic analysis solutions. Sequenom develops innovative technology, products and diagnostic tests that target and serve discovery and clinical research, and molecular diagnostics markets. The company was founded in 1994 and is headquartered in San Diego, California. Sequenom maintains a Web site at https://www.sequenom.com to which Sequenom regularly posts copies of its press releases as well as additional information about Sequenom. Interested persons can subscribe on the Sequenom Web site to email alerts or RSS feeds that are sent automatically when Sequenom issues press releases, files its reports with the Securities and Exchange Commission or posts certain other information to the Web site.

SEQUENOM® is a registered trademark of Sequenom, Inc.

Forward-Looking Statements

Except for the historical information contained herein, the matters set forth in this press release, including statements regarding the Company’s anticipated retention as a consultant and subsequent employment of Mr. Maier and the Company’s financial position and positioning for product launches and growth, are forward-looking statements within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. These forward-looking statements are subject to risks and uncertainties that may cause actual results to differ materially, including the risks and uncertainties associated with the Company’s ability to retain and employ Mr. Maier, the Company’s ability to strengthen its financial position, position itself for product launches and growth and develop and commercialize new technologies and products, particularly new technologies such as genetic analysis platforms, noninvasive prenatal diagnostics and laboratory developed tests, reliance upon the collaborative efforts of other parties, the Company’s ability to manage its existing cash resources or raise additional cash resources, competition, intellectual property protection and intellectual property rights of others, government regulation particularly with respect to diagnostic products and laboratory developed tests, obtaining or maintaining regulatory approvals, and other risks detailed from time to time in the Company’s Annual Report on Form 10-K for the year ended December 31, 2008 and other documents subsequently filed with or furnished to the Securities and Exchange Commission. These forward-looking statements are based on current information that may change and you are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. All forward-looking statements are qualified in their entirety by this cautionary statement, and the Company undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.

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