COLUMBIA, Md. — Shimadzu Scientific Instruments introduces the Nexera X4 Ultra High-Performance Liquid Chromatograph (UHPLC), a next-generation system that builds on the proven technology of Shimadzu’s Nexera series. With its industry-leading low-dispersion design, the Nexera X4 UHPLC delivers superior sensitivity, ultra-sharp peaks and outstanding separation performance. Advanced fluid control technology maintains exceptional flow stability during high-speed, ultra-high-pressure analyses for consistently reliable results. The system is ideal for research and development applications in pharmaceuticals, food, environmental science and chemistry.Features of the Nexera X4 UHPLC include:

 Ultra-Fast Analysis

With its new four-drive binary pump, independently activated plungers and pressure feedback control, the Nexera X4 UHPLC enables ultra-fast analysis through highly responsive solvent delivery. The instrument cuts analysis times by 92% versus typical HPLC systems and 78% versus other UHPLC-class systems, delivering up to 14 times greater laboratory productivity.

Ultra-Sharp Peaks

The Nexera X4 incorporates Shimadzu’s Nexflow technology to minimize system-derived peak broadening through low-dispersion flow paths that maintain the internal diameter of the flow lines. This feature increases sensitivity, enables full UHPLC column performance and delivers higher separation efficiency.

Ultra-Low Solvent Consumption

Used with narrow-bore columns, the Nexera X4 UHPLC significantly reduces solvent consumption, enabling more cost-efficient and environmentally conscious analysis.

Optimized for Analytical Miniaturization

The Nexera X4 UHPLC supports analytical miniaturization through its precise micro-volume injection, accurate mobile phase delivery and low-dispersion flow paths that minimize band broadening, even with narrow-bore columns.

Maximize Mass Spectrometry Performance

The Nexflow tubing kit reduces peak broadening between the column outlet and MS interface, leveraging the ultra-fast and high-separation performance of the Nexera X4 UHPLC and maximizing mass spectrometer performance.

A Next-Generation LCMS Platform

Paired with Shimadzu’s triple quad LCMS-TQ RX Series systems, the Nexera X4 UHPLC delivers high-speed, high-sensitivity LC-MS/MS analysis. With UFswitching™ technology, the LCMS-TQ RX Series supports positive and negative ionization switching in just 5 msec, minimizing ion intensity loss and enabling stable, high-sensitivity results. Combined with the Nexera X4’s excellent gradient control, the system offers exceptional throughput for demanding analytical workflows.

For more information, visit the Nexera X4 UHPLC web page.

 About Shimadzu Scientific Instruments Inc. 

Shimadzu Scientific Instruments (SSI) is the North American subsidiary of Shimadzu Corporation’s Analytical and Measuring Division. Headquartered in Columbia, Maryland, SSI offers a comprehensive portfolio of analytical and testing solutions for a broad range of applications in science and industry. SSI maintains a network of ten regional offices strategically located across the United States, with experienced technical specialists, service providers and sales engineers situated throughout the country. In addition, SSI operates a Solution Center, designed to enable applications development, and an R&D Center that houses a team of scientists whose goal is to develop close collaborations with universities, government agencies and industry centers. Visit www.ssi.shimadzu.com/ for more information.