LANCASTER, Calif. – Simulations Plus, Inc. (NASDAQ: SLP), a leading provider of simulation and modeling software for pharmaceutical discovery and development, announced today the launch of a new freely available software product called MedChem Designer™ to complement its MedChem Studio™ and ADMET Predictor™ offerings for the design of pharmaceutical and other new molecular structures.

Unique features of MedChem Designer include:

Intuitive interface with many innovative features for molecular structure drawing and manipulation

Several free predicted key molecular properties from our top-rated ADMET Predictor software

With a full ADMET Predictor license, a wide range of predicted properties:

Physicochemical properties

Pharmacokinetic parameters

Cytochrome P450 (CYP) enzyme metabolism rates

CYP inhibition

Sites of CYP oxidation

UGT metabolism

Over 30 potential toxicities

Partial atomic charges and reactivities based on our proprietary rapid quantum chemical descriptor calculations

Dr. David Miller, team leader for discovery cheminformatics at Simulations Plus, said: “MedChem Designer was developed to be the most flexible and powerful molecular drawing tool available today. Chemists who design new compounds for pharmaceutical, cosmetic, industrial chemical, herbicide, pesticide, and food applications will enjoy the highly intuitive interface with a number of convenience features and innovative capabilities not available in other molecule drawing software. Unlike other molecule drawing programs, MedChem Designer provides the chemist with the world’s most accurate predictions for a wide-range of properties with a full ADMET Predictor license, or for a few key properties in the freely available version. The ability of a chemist to sketch a molecule, then rapidly evaluate multiple potential modifications to the structure in seconds, including the rapid atomic property calculations from ADMET Predictor, provides a unique capability in the world of chemical design.”

Walt Woltosz, chairman and chief executive officer of Simulations Plus, added: “For years, we’ve wanted to have a good molecule drawing program to integrate into our product line. We made attempts to acquire this capability without success. Dr. Miller took advantage of the excellent molecule depiction capabilities he had developed for MedChem Studio™ and ADMET Predictor™ as the basis for developing our own drawing program. The result is a molecule design tool that is both intuitive and powerful. Several such tools exist on the market and most of the companies that make them provide them for free. MedChem Designer will also be free as a standalone product. What sets it apart is not only the list of features that make drawing and modifying molecular structures faster and easier, but also the almost instant calculation of properties of interest to chemists from our best-in-class suite of ADMET Predictor™ models.”

Mr. Woltosz continued, “We believe that a very friendly molecule drawing tool integrated with a few of the world’s best predictions freely provided for a few key properties will entice chemists to try MedChem Designer and then want to use ADMET Predictor with it to see the complete picture regarding the effects of changing molecular structures. Chemists want to know as much as possible about the consequences of each change they consider making to a new molecule. Once they license the full range of ADMET Predictor capabilities, over 120 properties can be generated in seconds for each change to a molecule. This enables them to modify a structure in one or more ways and quickly see if their changes are predicted to result in better properties or worse ones. The unique ADMET Risk™ score in ADMET Predictor generates a single number along with a set of codes that instantly inform the chemist of which, if any, of a large number of rules relevant to drug design are violated by the new structure.”

About Simulations Plus, Inc.

Simulations Plus, Inc., is a premier developer of groundbreaking drug discovery and development simulation and modeling software, which is licensed to and used in the conduct of drug research by major pharmaceutical and biotechnology companies worldwide. The Company’s Words+, Inc., wholly owned subsidiary provides augmentative communication systems and other technologies for persons with disabilities. Simulations Plus is headquartered in Southern California. For more information, visit our web site at www.simulations-plus.com.

Safe Harbor Statement Under the Private Securities Litigation Reform Act of 1995 – With the exception of historical information, the matters discussed in this press release are forward-looking statements that involve a number of risks and uncertainties. Words like “believe,” “expect” and “anticipate” mean that these are our best estimates as of this writing, but that there can be no assurances that expected or anticipated results or events will actually take place, so our actual future results could differ significantly from those statements. Factors that could cause or contribute to such differences include, but are not limited to: the acceptance by our customers of MedChem Designer and its capabilities, our ability to maintain our competitive advantages, the general economics of the pharmaceutical industry, our ability to finance growth, our ability to continue to attract and retain highly qualified technical staff, our ability to identify and close acquisitions on terms favorable to the Company, and a sustainable market. Further information on our risk factors is contained in our quarterly and annual reports as filed with the U.S. Securities and Exchange Commission.