 Granted patents confirm innovation and novelty of proteomics product range  Strengthens OEM deals and non-exclusive out licensing possibilities  Enhences competitive edge supporting expansion Madrid, Spain, and Heidelberg, Germany – SYGNIS AG (Frankfurt: LIO1; ISIN: DE000A1RFM03; Prime Standard) today announced it had been granted broad patents in Europe and China. The patent granted by the European Patent Office (EPO) titled: “Methods and Kits for Folding Proteins in the Presence of Linear or Branched Sugar Polymers” covers SYGNIS’ NVoy technology for use in protein folding applications. Proteins require a specific three dimensional confirmation in order to be functional. When proteins of interest, such as protein drugs, are expressed in host cells they often aggregate or misfold. The Nvoy technology uses a novel type of amphipathic polymers which protect the proteins against aggregation and assist with the folding into functional proteins. The patent granted by the State Intellectual Property Office of the People’s Republic of China (SIPO), titled: “Protein Detection Reagents and Methods with Dyes and Dextrins” covers protein detection methods. While proteins are invisible to the naked eye researchers often require accurate visualisation and quantitation of these molecules. SYGNIS offers proteomics products such as InstantBlue and Bradford Ultra which enable fast and accurate visible detection and quantitation of proteins. These products are covered by patents worldwide. Dr. Heikki Lanckriet, Co-CEO and CSO of SYGNIS said: “These new granted patents further corroborate the innovation and novelty of SYGNIS’ proteomics product range. The broad patent coverage obtained for our products gives the Company a strong competitive edge, which will help to facilitate SYGNIS’ global expansion and the related growth in sales and revenues.” About SYGNIS AG: SYGNIS AG is specialized in the development and the commercialization of proprietary technologies and offers a wide range of different commercial products addressing key challenges in molecular biology. With the acquisition of Expedeon Holdings, Ltd. based in Cambridge, UK, SYGNIS has added a complementary proteomic product portfolio. Resulting from this significant expansion, SYGNIS’ product portfolio now covers the entire workflow of molecular biology. The products are sold through a direct sales force and several distribution partners in Europe, the US and Asia. SYGNIS AG has offices in Germany, Spain and the UK, production sites in the UK and the US as well as sales offices in Asia. The company is listed on the German Stock Exchange in Frankfurt in the Prime Standard segment (Ticker: LIO1; ISIN: DE000A1RFM03). www.sygnis.com