Technology brings university scientists unparalleled potential for chemical, biological and human disease research First commercial research instrument of its kind in the world. MILFORD, Mass.–(BUSINESS WIRE)– Aston University and Waters Corporation (NYSE: WAT) announced today the completed installation of the world’s first Waters™ SELECT SERIES™ Cyclic™ IMS (ion mobility spectrometry) mass spectrometer within the University’s School of Health and Life Sciences, where the instrument will support research into the biology of human diseases, the discovery of new therapeutics and advances in biotechnology. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20191107005188/en/ Waters Corporation has completed the installation of the world’s first SELECT SERIES Cyclic IMS mass spectrometer within the School of Health Sciences at Aston University (Birmingham, England). (Photo: Business Wire) Waters Corporation has completed the installation of the world’s first SELECT SERIES Cyclic IMS mass spectrometer within the School of Health Sciences at Aston University (Birmingham, England). (Photo: Business Wire) Mass spectrometry (MS) is a widely deployed analytical method used by scientists to identify and quantify molecules in a sample and determine their detailed molecular structure. For example, it can be used to more effectively identify disease biomarkers that allow for early detection. Ion mobility spectrometry is a proven technique that separates ions by their size, shape and charge. The SELECT SERIES Cyclic IMS takes ion mobility to a new level, replacing the traditional linear ion mobility region with a novel compact cyclic device. Ions traverse around the cyclic region and with every pass greater ion mobility resolution is achieved. In addition, the advanced technology enables the unique ability to perform ion mobility selection for ion mobility/ion mobility and IMSn experiments. The new instrument will be used by researchers at Aston University and across the Midland Innovation consortium to answer complex biological questions. Andrew Pitt, Professor of Pharmaceutical Chemistry & Chemical Biology, Aston University said: “We are delighted to have this new technology in our lab here at Aston; it will provide us and other researchers in the Midlands with a step change in how we conduct our research. “The new instrument is one of a relatively recent class of mass spectrometers, incorporating ion mobility, which separate molecules based not only on their mass but also by their shape. This allows us to see what is going on in biology in much more detail, including information we are able to gain from the shape of molecules that will allow us to solve much more complex questions.” Combining novel IMS capability with significantly improved mass spectrometry performance and enabling software, this platform allows leading researchers to unlock the potential in scientific discovery. Jim Langridge, Advanced MS Technologies Waters Corporation said: “Human biology is extraordinarily complex and the SELECT SERIES Cyclic IMS gives research scientists the ability to probe deeper into the chemistry and biology of human disease like never before. “By collaborating with leading researchers like Professor Pitt, we continually advance the science of mass spectrometry, accelerating their research into human health and well-being.” Aston University scientists will run a visiting researcher programme that will allow researchers from many disciplines to visit Aston and work with the first-of-its-kind SELECT SERIES Cyclic IMS instrument, exploring its unparalleled experimental potential. The journal Analytical Chemistry documented the effectiveness and power of the cyclic IMS instrument in a recent article titled: A Cyclic Ion Mobility – Mass Spectrometry System. About Aston University Founded in 1895 and a University since 1966, Aston is a long established university led by its three main beneficiaries – students, business and the professions, and our region and society. Aston University is located in Birmingham and at the heart of a vibrant city and the campus houses all the university’s academic, social and accommodation facilities for our students. Professor Alec Cameron is the Vice Chancellor & Chief Executive. About Waters Corporation Waters Corporation (NYSE: WAT), the world’s leading specialty measurement company, has pioneered chromatography, mass spectrometry and thermal analysis innovations serving the life, materials and food sciences for more than 60 years. With approximately 7,200 employees worldwide, Waters operates directly in 35 countries, including 15 manufacturing facilities, and with products available in more than 100 countries. Waters and SELECT SERIES are trademarks of Waters Corporation.

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Cambridge, UK – Abcam’s new engineered knockout cell lysates enable proteomic studies by providing researchers with “true negative” controls.

Acquiring reliable off-the-shelf knockout mouse models or cell lines that match specific experimental requirements can be challenging, and often need to be sourced directly from individual researchers or labs. Abcam’s newly-launched collection addresses this issue by providing access to over 2,800 diploid KO cell lysates, the largest selection currently available to researchers.

The lysates are useful for studies requiring loss-of-function phenotypes at the proteomic level as well as routine applications such as Western blotting and mass spectroscopy. They also can be used to support antibody and target validation. The use of diploid cells makes the lysates well suited to the more complex studies often carried out in cancer research.

Derived from commonly used immortalized cell lines, KO lysates have been engineered using CRISPR-Cas9 and are accompanied by Sanger sequencing and Western blotting validation data. Corresponding wild-type controls are also provided so that the biological impact of each KO lysate can easily be assessed within a consistent cellular background.

Abcam’s KO cell lysates deliver:

  • Access to thousands of CRISPR-Cas9-engineered KO cell lysates of interest, without needing to generate or purchase a KO cell line, saving on average 4–12 weeks’ work in the lab
  • Minimal preparation required
  • Diploid KO lysates derived from commonly used cell lines including HeLa, HEK293T, A549, HCT116, Hep G2 and MCF
Abcam Human TOMM34 KO HeLa Cell Lysate Refrigerated and Frozen Shipping Systems
Abcam Human TOMM34 KO HeLa Cell Lysate x2
Please contact [email protected] for any high resolution images of the product.
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Notes To Editors

About Abcam plc
As a global life sciences company, Abcam identifies, develops, and distributes high-quality biological reagents and tools that are crucial to research, drug discovery and diagnostics. Working across the industry, the Company supports life scientists to achieve their mission, faster. Abcam partners with life science organisations to co-create novel binders for use in drug discovery, in vitro diagnostics and therapeutics, driven by the Company’s proprietary discovery platforms and world-leading, antibody expertise. By constantly innovating its binders and assays, Abcam is helping advance the global understanding of biology and causes of disease, which enables new treatments and improved health. The Company’s pioneering data-sharing approach gives scientists increased confidence in their results by providing validation, user comments and peer-reviewed citations for its 110,000 products. With eleven sites globally, many of Abcam’s 1,100 strong team are located in the world’s leading life science research hubs, complementing a global network of services and support.

To find out more, please visit www.abcam.com and www.abcamplc.com.
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