Building on the cross-industry standard Thermo Scientific Helios Hydra DualBeam platform, the Hydra Bio Plasma-FIB is a versatile, multi-application instrument that supports volume electron microscopy and sample preparation for the cryo-electron tomography workflow. From tissues to proteins, this instrument is designed to be a bridge from cryo-EM to room temperature analysis or vice versa, and to help cell biologists spend more time focused on advancing their complex research projects.

• Volume electron microscopy: the Hydra Bio Plasma-FIB supports various microscopy techniques, such as FIB-SEM serial sectioning (at room temperature and cryogenic conditions), array tomography, and cryo-electron tomography, allowing biomedical researchers to study the 3D complexities of cells, tissue and small organisms at nanometer resolution.
• Multiple ion species: users can quickly switch between four ion species (Xe, Ar, O, and N) to optimize for the specific requirements of each sample.
• Cryogenic operation: researchers can investigate cellular architecture, in native conditions, and with excellent contrast. They can uncover sub-cellular details on high-pressure-frozen and plunge-frozen samples with no staining required.
• Room temperature operation: cell biologists can uncover large sample areas and visualize regions of interest with the Spin Mill Bio Method. This unique large area planar-milling technique generates areas of similar size as microtome slicing, but at slice thicknesses as small as 5 nm. Prepare clean, smooth surfaces used to localize regions of interest and subsequently image them in 2D or 3D.

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