Zyoxel Announces the Performance of Tests by Sanofi on the Power of 3D Liver Culture Models for More Predictive and Insightful DMPK Studies

OXFORD, England — Zyoxel, the world’s leading expert for advanced in vitro 3D liver models for drug discovery and drug testing, has announced preliminary results from a testing by Sanofi on Zyoxel’s LiverChip™ platform for drug metabolism and pharmacokinetic (DMPK) studies. Sanofi employed a variety of morphological, genetic and functional analyses to fully characterise the LiverChip™ system, the full findings of which will be presented as part of Zyoxel’s In Vitro Liver Technology Symposium taking place on December 10, 2013 in Oxford, UK.

Under the terms of an Equipment Hire Agreement, Sanofi, an integrated global healthcare leader, has been exploring the utility of Zyoxel’s LiverChip™ platform. During the project, which commenced in December 2012 and involved the installation of a LiverChip™ device at a Sanofi research site, the company tested the human hepatocyte LiverChip™ system against current industry gold standard 2D plated cultures of primary hepatocytes.

Using LiverChip™, Sanofi’s researchers were able to perform in depth DMPK analyses over much longer time courses of up to 6 days, including the accurate monitoring of dose clearance by the cytochrome P450 enzyme superfamily (CYPs), as well as the induction of CYP isoforms during drug metabolism. The study also confirmed that LiverChip™ does not suffer from any non-specific drug binding, while the results exhibited good reproducibility, both within individual plates and between replicate experiments.

For further details about the LiverChip™ technology, please visit Zyoxel’s website.

About Zyoxel

Zyoxel has developed and fully commercialized the world’s most physiologically accurate in vitro 3D liver model. Their products and services are used by pharmaceutical companies to predict the clinical safety and pharmacological properties of new drugs. Zyoxel’s platform is based upon innovative technologies developed at the University of Oxford and the Massachusetts Institute of Technology. The company was spun out of Oxford University’s Institute of Biomedical Engineering in 2009 with investment from Hong Kong multinational CN Innovations Holdings.

Contacts

Commercial Enquiries

Zyoxel Ltd

Ian Taylor

Sales

+44 (0) 7554 446 185

ian.taylor@zyoxel.com

www.zyoxel.com

Media Enquiries

Chempetitive Group (UK office)

Sam Marsden

Account Manager

+44 (0) 1223 828 200

smarsden@chempetitive.com

Zyoxel Announces the Performance of Tests by Sanofi on the Power of 3D Liver Culture Models for More Predictive and Insightful DMPK Studies

Sort Results

Sort Results

Contact Us

Pay Invoice

Your Data and Privacy

Search All
Volume 29, Issue 12 - October 01, 2020
Volume 28, Issue 20 - January 31, 2020
Volume 28, Issue 19 - January 15, 2020
Volume 28, Issue 18 - January 03, 2020
Volume 28, Number 14 - November 30, 2019
Volume 28, Issue 8 - July 31, 2019
Volume 28, Issue 3 - May 15, 2019
Volume 28, Issue 2 - April 30, 2019
Volume 28, Issue 1 - April 15, 2019
Volume 27, Issue 24 - March 31, 2019
Volume 27, Issue 23 - March 15, 2019
Volume 27, Issue 22 - February 28, 2019
Volume 27, Issue 21 - February 15, 2019
Volume 27, Issue 20 - January 31, 2019
Volume 27, Issue 19 - January 15, 2019
Volume 27, Issue 18 - December 31, 2018
Volume 27, Issue 17 - December 15, 2018
Volume 27, Issue 16 - November 30, 2018
Volume 27, Issue 15 - November 15, 2018
Volume 27, Issue 14 - October 31, 2018
Volume 27, Issue 13 - October 15, 2018
Volume 27, Issue 12 - September 30, 2018
Volume 27, Issue 11 - September 15, 2018
Volume 27, Issue 10 - August 31, 2018
Volume 27, Issue 9 - August 15, 2018
Volume 27, Issue 8 - July 31, 2018
Volume 27, Issue 7 - July 16, 2018
Volume 27, Issue 6 - June 30, 2018
Volume 27, Issue 5 - June 15, 2018
Volume 27, Issue 4 - May 31, 2018
Volume 27, Issue 3 - May 15, 2018
Volume 27, Issue 2 - April 30, 2018
Volume 27, Issue 1 - April 15, 2018
Volume 26, Issue 24 - March 31, 2018
Volume 26, Issue 23 - March 15, 2018
Volume 26, Issue 22 - February 28, 2018
Volume 26, Issue 21 - February 15, 2018
Volume 26, Issue 20 - January 31, 2018
Volume 26, Issue 18 - December 31, 2017
Volume 26, Issue 17 - December 15, 2017
Volume 26, Issue 16 - November 30, 2017
Volume 26, Issue 15 - November 15, 2017
Volume 26, Issue 14 - October 31, 2017
Volume 26, Issue 13 - October 15, 2017
Volume 26, Issue 12 - September 30, 2017
Volume 26, Issue 11 - September 15, 2017
Volume 26, Issue 10 - August 31, 2017
Volume 26, Issue 9 - August 15, 2017
Volume 26, Issue 8 - July 31, 2017
Volume 26, Issue 7 - July 15, 2017
Volume 26, Issue 6 - June 30, 2017
Volume 26, Issue 5 - June 15, 2017
Volume 26, Issue 4 - May 31, 2017
Volume 26, Issue 3 - May 15, 2017
Volume 26, Issue 2 - April 30, 2017
Volume 26, Issue 1 - April 15, 2017
Volume 25, Issue 24 - March 31, 2017
Volume 25, Issue 23 - March 15, 2017
Volume 25, Issue 22 - February 28, 2017
Volume 25, Issue 21 - February 15, 2017
Volume 25, Issue 20 - January 31, 2017
Volume 25, Issue 18 - December 31, 2016
Volume 25, Issue 17 - December 15, 2016
Volume 25, Issue 16 - November 30, 2016
Volume 25, Issue 15 - November 15, 2016
Volume 25, Issue 14 - October 31, 2016
Volume 25, Issue 13 - October 15, 2016
Volume 25, Issue 12 - September 30, 2016
Volume 25, Issue 11 - September 15, 2016
Volume 25, Issue 10 - August 31, 2016
Volume 25, Issue 9 - August 15, 2016
Volume 25, Issue 8 - July 31, 2016
Volume 25, Issue 7 - July 15, 2016
Volume 25, Issue 6 - June 30, 2016
Volume 25, Issue 5 - June 15, 2016
Volume 25, Issue 4 - May 31, 2016
Volume 25, Issue 3 - May 15, 2016
Volume 25, Issue 2 - April 30, 2016
Volume 25, Issue 1 - April 15, 2016
Volume 24, Issue 24 - March 31, 2016
Volume 24, Issue 23 - March 15, 2016
Volume 24, Issue 22 - February 29, 2016
Volume 24, Issue 21 - February 15, 2016
Volume 24, Issue 20 - January 31, 2016
Volume 24, Issue 18 - December 31, 2015
Volume 24, Issue 17 - December 15, 2015
Volume 24, Issue 16 - November 30, 2015
Volume 24, Issue 15 - November 15, 2015
Volume 24, Issue 14 - October 31, 2015
Volume 24, Issue 13 - October 15, 2015
Volume 24, Issue 12 - September 30, 2015
Volume 24, Issue 11 - September 15, 2015
Volume 24, Issue 10 - August 31, 2015
Volume 24, Issue 9 - August 15, 2015
Volume 24, Issue 8 - July 31, 2015
Volume 24, Issue 7 - July 15, 2015
Volume 24, Issue 6 - June 30, 2015
Volume 24, Issue 5 - June 15, 2015
Volume 24, Issue 4 - May 31, 2015
Volume 24, Issue 3 - May 15, 2015
Volume 24, Issue 2 - April 30, 2015
Volume 24, Issue 1 - April 15, 2015
Volume 23, Issue 24 - March 31, 2015
Volume 23, Issue 23 - March 15, 2015
Volume 23, Issue 22 - February 28, 2015
Volume 23, Issue 21 - February 15, 2015
Volume 23, Issue 20 - January 31, 2015
Volume 23, Issue 19 - January 15, 2015
Volume 23, Issue 18 - December 31, 2014
Volume 23, Issue 17 - December 15, 2014
Volume 23, Issue 16 - November 30, 2014
Volume 23, Issue 15 - November 15, 2014
Volume 23, Issue 14 - October 31, 2014
Volume 23, Issue 13 - October 15, 2014
Volume 23, Issue 12 - September 30, 2014
Volume 23, Issue 11 - September 15, 2014
Volume 23, Issue 10 - August 31, 2014
Volume 23, Issue 9 - August 15, 2014
Volume 23, Issue 8 - July 31, 2014
Volume 23, Issue 7 - July 15, 2014
Volume 23, Issue 6 - June 30, 2014
Volume 23, Issue 5 - June 15, 2014
Volume 23, Issue 4 - May 31, 2014
Volume 23, Issue 3 - May 15, 2014
Volume 23, Issue 2 - April 30, 2014
Volume 23, Issue 1 - April 15, 2014
Volume 22, Issue 24 - March 31, 2014
Volume 22, Issue 23 - March 15, 2014
Volume 22, Issue 22 - February 28, 2014
Volume 22, Issue 21 - February 15, 2014
Volume 22, Issue 20 - January 31, 2014
Volume 22, Issue 19 - January 15, 2014
Volume 22, Issue 18 - December 31, 2013
Volume 22, Issue 17 - December 15, 2013
Volume 22, Issue 16 - November 30, 2013
Volume 22, Issue 15 - November 15, 2013
Volume 22, Issue 14 - October 31, 2013
Volume 22, Issue 13 - October 15, 2013
Volume 22, Issue 12 - September 30, 2013
Volume 22, Issue 11 - September 15, 2013
Volume 22, Issue 10 - August 31, 2013
Volume 22, Issue 9 - August 15, 2013
Volume 22, Issue 8 - July 31, 2013
Volume 22, Issue 7 - July 15, 2013
Volume 22, Issue 6 - June 30, 2013
Volume 22, Issue 5 - June 15, 2013
Volume 22, Issue 4 - May 31, 2013
Volume 22, Issue 3 - May 15, 2013
Volume 22, Issue 2 - April 30, 2013
Volume 22, Issue 1 - April 15, 2013
Volume 21, Issue 24 - March 31, 2013
Volume 21, Issue 23 - March 15, 2013
Volume 21, Issue 22 - February 28, 2013
Volume 21, Issue 21 - February 15, 2013
Volume 21, Issue 20 - January 31, 2013
Volume 21, Issue 19 - January 15, 2013
Volume 21, Issue 18 - December 31, 2012
Volume 21, Issue 17 - December 15, 2012
Volume 21, Issue 16 - November 30, 2012
Volume 21, Issue 15 - November 15, 2012
Volume 21, Issue 14 - October 31, 2012
Volume 21, Issue 13 - October 15, 2012
Volume 21, Issue 12 - September 30, 2012
Volume 21, Issue 11 - September 15, 2012
Volume 21, Issue 10 - August 31, 2012
Volume 21, Issue 9 - August 15, 2012
Volume 21, Issue 8 - July 31, 2012
Volume 21, Issue 7 - July 15, 2012
Volume 21, Issue 6 - June 30, 2012
Volume 21, Issue 5 - June 15, 2012
Volume 21, Issue 4 - May 31, 2012
Volume 21, Issue 3 - May 15, 2012
Volume 21, Issue 2 - April 30, 2012
Volume 21, Issue 1 - April 15, 2012
Volume 20, Issue 24 - March 31, 2012
Volume 20, Issue 23 - March 15, 2012
Volume 20, Issue 22 - February 29, 2012
Volume 20, Issue 21 - February 15, 2012
Volume 20, Issue 20 - January 31, 2012
Volume 20, Issue 19 - January 15, 2012
Volume 20, Issue 18 - December 31, 2011
Volume 20, Issue 17 - December 15, 2011
Volume 20, Issue 16 - November 30, 2011
Volume 20, Issue 15 - November 15, 2011
Volume 20, Issue 14 - October 31, 2011
Volume 20, Issue 13 - October 15, 2011
Volume 20, Issue 12 - September 30, 2011
Volume 20, Issue 11 - September 15, 2011
Volume 20, Issue 10 - August 31, 2011
Volume 20, Issue 9 - August 15, 2011
Volume 20, Issue 8 - July 31, 2011
Volume 20, Issue 7 - July 15, 2011
Volume 20, Issue 6 - June 30, 2011
Volume 20, Issue 5 - June 15, 2011
Volume 20, Issue 4 - May 31, 2011
Volume 20, Issue 3 - May 15, 2011
Volume 20, Issue 2 - April 30, 2011
Volume 20, Issue 1 - April 15, 2011
Volume 19, Issue 24 - March 31, 2011
Volume 19, Issue 23 - March 15, 2011
Volume 19, Issue 22 - February 28, 2011
Volume 19, Issue 21 - February 15, 2011
Volume 19, Issue 20 - January 31, 2011
Volume 19, Issue 19 - January 15, 2011
Volume 19, Issue 18 - December 31, 2010
Volume 19, Issue 17 - December 15, 2010
Volume 19, Issue 16 - November 30, 2010
Volume 19, Issue 15 - November 15, 2010
Volume 19, Issue 14 - October 31, 2010
Volume 19, Issue 13 - October 15, 2010
Volume 19, Issue 12 - September 30, 2010
Volume 19, Issue 11 - September 15, 2010
Volume 19, Issue 10 - August 31, 2010
Volume 19, Issue 9 - August 15, 2010
Volume 19, Issue 8 - July 31, 2010
Volume 19, Issue 7 - July 15, 2010
Volume 19, Issue 6 - June 30, 2010
Volume 19, Issue 5 - June 15, 2010
Volume 19, Issue 4 - May 31, 2010
Volume 19, Issue 3 - May 15, 2010
Volume 19, Issue 2 - April 30, 2010
Volume 19, Issue 1 - April 15, 2010
Volume 18, Issue 24 - March 31, 2010
Volume 18, Issue 23 - March 15, 2010
Volume 18, Issue 22 - February 28, 2010
Volume 18, Issue 21 - February 15, 2010
Volume 18, Issue 20 - January 31, 2010
Volume 18, Issue 19 - January 15, 2010
Volume 18, Issue 18 - December 31, 2009
Volume 18, Issue 17 - December 15, 2009
Volume 18, Issue 16 - November 30, 2009
Volume 18, Issue 15 - November 15, 2009
Volume 18, Issue 14 - October 31, 2009
Volume 18, Issue 13 - October 15, 2009
Volume 18, Issue 12 - September 30, 2009
Volume 18, Issue 11 - September 15, 2009
Volume 18, Issue 10 - August 31, 2009
Volume 18, Issue 9 - August 15, 2009
Volume 18, Issue 8 - July 31, 2009
Volume 18, Issue 7 - July 15, 2009
Volume 18, Issue 6 - June 30, 2009
Volume 18, Issue 5 - June 15, 2009
Volume 18, Issue 4 - May 31, 2009
Volume 18, Issue 3 - May 15, 2009
Volume 18, Issue 2 - April 30, 2009
Volume 18, Issue 1 - April 15, 2009
Volume 17, Issue 24 - March 31, 2009
Volume 17, Issue 23 - March 15, 2009
Volume 17, Issue 22 - February 28, 2009
Volume 17, Issue 21 - February 15, 2009
Volume 17, Issue 20 - January 31, 2009
Volume 17, Issue 19 - January 15, 2009
Volume 17, Issue 18 - December 31, 2008
Volume 17, Issue 17 - December 15, 2008
Volume 17, Issue 16 - November 30, 2008
Volume 17, Issue 15 - November 15, 2008
Volume 17, Issue 14 - October 31, 2008
Volume 17, Issue 13 - October 15, 2008
Volume 17, Issue 12 - September 30, 2008
Volume 17, Issue 11 - September 15, 2008
Volume 17, Issue 10 - August 31, 2008
Volume 17, Issue 9 - August 15, 2008
Volume 17, Issue 8 - July 31, 2008
Volume 17, Issue 7 - July 15, 2008
Volume 17, Issue 6 - June 30, 2008
Volume 17, Issue 5 - June 15, 2008
Volume 17, Issue 4 - May 31, 2008
Volume 17, Issue 3 - May 15, 2008
Volume 17, Issue 2 - April 30, 2008
Volume 17, Issue 1 - April 15, 2008
Volume 16, Issue 24 - March 31, 2008
Volume 16, Issue 23 - March 15, 2008
Volume 16, Issue 22 - February 29, 2008
Volume 16, Issue 21 - February 15, 2008
Volume 16, Issue 20 - January 31, 2008
Volume 16, Issue 19 - January 15, 2008
Volume 16, Issue 18 - December 31, 2007
Volume 16, Issue 17 - December 15, 2007
Volume 16, Issue 16 - November 30, 2007
Volume 16, Issue 15 - November 15, 2007
Volume 16, Issue 14 - October 31, 2007
Volume 16, Issue 13 - October 15, 2007
Volume 16, Issue 12 - September 30, 2007
Volume 16, Issue 11 - September 15, 2007
Volume 16, Issue 10 - August 31, 2007
Volume 16, Issue 9 - August 15, 2007
Volume 16, Issue 8 - July 31, 2007
Volume 16, Issue 7 - July 15, 2007
Volume 16, Issue 6 - June 30, 2007
Volume 16, Issue 5 - June 15, 2007
Volume 16, Issue 4 - May 31, 2007
Volume 16, Issue 3 - May 15, 2007
Volume 16, Issue 2 - April 30, 2007
Volume 16, Issue 1 - April 15, 2007
Volume 15, Issue 24 - March 31, 2007
Volume 15, Issue 23 - March 15, 2007
Volume 15, Issue 21 - February 15, 2007
Volume 15, Issue 20 - January 31, 2007
Volume 34, Issue 21
Volume 34, Issue 15
Volume 28, Issue 9
Volume 28, Issue 4

Search All
Ag/Food
Applied Markets
Asia-Pacific
Atomic Spectroscopy
Cell-based Analysis
Chemicals
Chromatography
Consumables (Aftermarket)
Corporate HR
Corporate HR|Lab Automation
Diagnostics
Electochemistry
Electrochemistry
Electrophoresis
Environmental
Europe
Financial
GC and GC/MS
General Analytical Techniques
In Vivo Animal Imaging
Industrial
Industry
Informatics
Instruments (Initial Systems)
Ion Mobility Spectrometry
Japan
Lab Automation
Lab Equipment
Lab Equipment|Laboratory Products
Laboratory Automation
Laboratory Products
Latin America
LC
Life Science Consumables
Life Science Instrumentation
Life Science Instrumentation|Microarrays
Life Science Instruments
Liquid Chromatography
Litigation
Mass Spectrometry
Mass Spectrometry and LC/MS
Materials Characterization
Mergers
Microarrays
Miniprep/Magnetic Beads
Molecular Spectroscopy
NMR
Nucleic Acid Amplification
Pharma/Bio/CROs
Process Analysis
Public Sector
Region
Rest-of-World
Sample Preparation
SamplePreparation
Security Technologies
Sequencing
Service
Surface Science
Synthesizers
USA/Canada

Sort Results

Sort Results

Contact Us

Pay Invoice

Latest Blogs

Sitemap

Your Data and Privacy

About Us