Bristol-Myers Squibb First Company to Contract for Symyx Solubility Services

SANTA CLARA, CA–Jul 24, 2008 — Symyx Technologies, Inc. (SMMX – News) announced today the launch of its new client-directed and collaborative research services for Life Sciences. These services allow clients to access Symyx’s installed base of parallel experimentation and testing capabilities through packaged offerings for solubility studies, polymorph screening, salt selection, co-crystallization, API stability in liquid and solid formulations, excipient compatibility, organic synthesis and process optimization.

Symyx recently signed a one-year agreement with Bristol-Myers Squibb Company (NYSE:BMY – News) for the use of Symyx Research Services for solubility studies. Under terms of the agreement, Symyx will perform solubility studies for Bristol-Myers Squibb through May, 2009.

“Symyx Research is continuing to transform its offerings into packaged, smaller scope and easily accessible solutions. Symyx Research Services combines our industry-leading research capabilities with real-time data analysis to deliver results on demand, freeing companies from internal capability constraints while substantially reducing the cost of R&D,” said Richard Boehner, President of Symyx Research. “We are pleased to enter this agreement with Bristol-Myers Squibb to provide solubility research services which will help them achieve a greater level of R&D efficiency.”

The benefits of Symyx Research Services include:

— Program flexibility: contract from a single experiment screen up to

tens-of-thousands of experiments per year.

— Access to experiment capability to execute and analyze hundreds of

experiments to deliver results in days not months.

— Greater experimental insight through development of more comprehensive

data sets through automated parallel experimentation than can be achieved

through traditional manual processes.

— Seamless replication of data and results to an existing customer-

managed Symyx database.

— Dynamic access to data sets using Symyx Software which allows

evaluation of full and raw data sets not static PDF reports.

For more information on Symyx Research visit: www.symyx.com/research/lifesciences

About Symyx

Symyx Technologies, Inc. is the scientific R&D integration partner to companies in the life sciences, chemicals, energy, electronics and consumer products industries. With scientific R&D under tremendous economic and technical pressure, we help companies reduce R&D risk and enhance R&D productivity to help them bring more and better products to market quickly and cost-effectively. Our integrated technology platform combines electronic laboratory notebooks, content, laboratory logistics and analysis available from Symyx Software, software-driven integrated workflows available from Symyx Tools and collaborative research and directed services from Symyx Research to support the entire R&D process. Information about Symyx, including reports and other information filed by Symyx with the Securities and Exchange Commission, is available at www.symyx.com.

Symyx is a registered trademark of Symyx Technologies, Inc. All rights reserved. All other trademarks mentioned in this document are the property of their respective owners.