This month, the US EPA updated to 70 parts per billion (ppb) the National Ambient Air Quality Standards for ground-level ozone. To meet the standard, the fourth-highest maximum daily eight-hour ozone concentration each year, averaged over three years, must not exceed 70 ppb. The changes are to both the primary (public health) and secondary (public […]

This month, the 1,000 Genomes Project published its final two papers, based on the analysis of 2,504 genomes of individuals from 26 populations in five continental regions. The broad sample gives insight into the level of normal genetic variation in humans. The first paper reported over 88 million genetic variants affecting up to 500 bases […]

The Centers for Medicare and Medicaid Services (CMS) has proposed a rule to implement the means to determine the rates paid for lab tests (see IBO 4/15/14). The CMS would require “applicable” labs—those with Clinical Laboratory Improvement Amendments certificates receiving more than half of their Medicare revenue from the clinical laboratory fee schedule (CLFS) or […]

A survey of 191 US universities, hospitals and research institutions, and one third-party technology investment firm showed gains in academic licensing and startup activity in 2014. These gains were despite a 5% drop in federal research funding to $37.9 billion. Respondents’ research expenditures overall fell 3.6% to $62.8 billion, but spending funded by industry rose […]

In 2016, the top 20 pharmaceutical companies’ sales of products gained through mergers and acquisitions are expected to match those of products developed within the companies. By net present value, only 36% of phase III drugs were internally developed, whereas 31%, 31% and 2% of them were obtained through acquisitions of companies, in-licensing and acquisitions […]

Based on the categorization of more than 35 million research papers into major disciplines by their journals of publication, and the proportion of references they cited from within or outside the same discipline, interdisciplinary research has been increasing since the mid-1980s. Three years following publication, the citation rates of articles decreased with the degree of […]

This month, the US FDA released its final Food Safety Modernization Act (FSMA) Preventive Controls for Human Food rule. Facilities subject to the rule must identify biological, chemical and physical hazards to food and institute preventive measures, such as sanitation controls and recall plans. The oversight of the controls consists of monitoring, corrections and verification, […]

Over the last several years, after the fall of iron ore and coal prices, mining companies have reduced spending on projects and exploration. Some major firms have cut capital spending by more than half. Now some investors are pushing companies to seek growth opportunities, believing that the current strategy leads to missed opportunities. One type […]

The American Society of Clinical Oncology (ASCO) last month released its policy statement on genetic and genomic testing for cancer susceptibility, updated in light of advances in NGS. The statement made recommendations in several areas. For example, ASCO encouraged providers to create and institute plans to determine and respond to patients’ preferences for receiving information […]

Spending on specialty drugs grew 26.5% last year to account for 33% of all US spending on prescription drugs, compared to 23% in 2010. Specialty drugs are often defined as “prescription products requiring extra handling or administration that are used to treat complex diseases including hepatitis C, multiple sclerosis and cancer.” The rise in expenditures […]