SAN PEDRO, Calif.–Celprogen Inc. has announced that they have successfully De-DIFFERENTIATED Human Somatic Cells (primary skin fibroblast, keratinocytes, cardiac, liver and neuronal cells) to their embryonic like pluripotent cells (iPCs).

This De-differentiation process was achieved with non-viral induction utilizing Celprogen’s De-differentiation media and matrix system for reprogramming adult somatic cells to iPCs in tissue culture.

The adult somatic cells were De-differentiated (reprogrammed) into their progenitor cell stage and then further de-differentiated into their resident pool of embryonic stem cell like linage. The de-differentiated somatic cells were further differentiated to the following tissue types in culture cardiac, neuronal and hepatocytes with Celprogen’s Stem Cell Differentiation system. The De-differentiation process is a non-viral process that brings promise for therapeutic applications in the near future.