Although there have been benchtop electron microscope products on the market for some time, the modern resurgence of benchtop electron microscopy began in 2005 with the release of Hitachi High-Technologies’ TM-1000. The TM-1000 is a scanning electron microscope providing magnification power of up to 10,000X, which is roughly an order of magnitude greater than can […]

High-throughput electroporators employ a microplate format, which allows simultaneous transfections of up to 384 wells. Electroporation introduces nucleic acids into cells by exposing the cells to a rapid pulse of voltage that causes the pores in the cells’ membranes to open temporarily. Unlike other transfection methods, there is no limit to the size of DNA […]

The quest to identify the ideal measure of water quality is an evolving saga and involves various analyses, such as dissolved oxygen, total organic carbon (TOC), chemical oxygen demand (COD) and biological oxygen demand (BOD). Developing reliable, easy-to-use instrumentation for such measurements is a challenge, but one that makers of COD analyzers are increasingly up […]

While instruments that measure the size and distribution of individual particles in a powder form a significant market, there is also an interesting but smaller market for instruments that measure the bulk properties of powders. These measurements are largely motivated by problems in industrial processing, where the behavior of powders passing through hoppers and bins, […]

In order for a protein to be introduced into an MS for identification, it must undergo a series of preparatory steps to ensure the cleanliness of the sample. Protein digestion is among those steps. Using a protease (most commonly trypsin), the protein is enzymatically digested into smaller pieces or peptides. Laboratory automation allows scientists to […]

Arc/spark spectroscopy is one of several atomic spectroscopy techniques that rely on optical emission spectroscopy (OES). The principle behind these techniques is to excite the atoms in the sample so that they emit their characteristic frequencies of light, which can be analyzed by the spectrometer to identify the individual elements present in the sample. With […]

The excitement about and focus on genomic sequencing stems from the high sales growth and untapped potential of massively parallel sequencing technologies, or next-generation sequencing (NGS). The current generation of sequencers employs similar chemistries, yet utilizes unique strategies. Roche’s Genome Sequencer FLX and GS Junior systems use a combination of emulsion PCR, and sequence by […]

Particle size analysis is one of a number of critical parameters that must be monitored at various stages of pharmaceutical and biopharmaceutical manufacturing. With high single-digit growth, global demand for process particle size analysis instrumentation for the pharmaceutical industry will be more than $30 million by 2012. The vendors that dominate the laboratory particle size […]

Secondary neutral MS (SNMS) is an interesting variation on secondary ion MS (SIMS). Both techniques provide sensitive analysis of the chemical composition of the sample surface, as well as the ability to probe layers beneath the surface in destructive depth-profiling applications. Despite the similarities, SNMS provides certain advantages that may be important for particular applications. […]